Browsing Biomedical Engineering (Scholarly Articles) by Title
Now showing items 96-115 of 128
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The past, present and future in scaffold-based tendon treatments
(Elsevier, 2015-04)Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ... -
A physical corrosion model for bioabsorbable metal stents
(2014)Absorbable metal stents (AMSs) are an emerging technology in the treatment of heart disease. Computational modelling of AMS performance will facilitate the development of this technology. In this study a physical corrosion ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part I: Theoretical Analysis
(2013)This paper presents a thorough analysis of potential-based and non-potential-based cohesive zone models (CZMs) under conditions of mixed-mode separation and mixed-mode over-closure. Problems are identified with the well ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part II: Finite element applications
(2013)This paper, the second of two parts, presents three novel finite element case studies to demonstrate the importance of normal-tangential coupling in cohesive zone models (CZMs) for the prediction of mixed-mode interface ... -
Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions
(Elsevier, 2020-03-04)The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can influence and control cell behaviour and function. While many studies ... -
Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions
(Springer, 2010-11)Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, ... -
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer, 2014-11-15)Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ... -
Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture
(AO Research Institute Davos, 2016-07-19)Bone marrow contains a multitude of mechanically sensitive cells that may participate in mechanotransduction. Primary cilia are sensory organelles expressed on mesenchymal stem cells (MSCs), osteoblasts, osteocytes, and ... -
Quality 4.0 conceptualization and theoretical understanding: A global exploratory qualitative study
(Emerald, 2021-08-17)This study provides a theoretical base for the Quality 4.0 body of knowledge in terms of an organisation s adoption and overcoming implementation challenges and providing examples of Quality 4.0 application. Organisations ... -
Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures
(Springer Verlag, 2016-06)Recent studies have shown that mechanical stimulation, in the form of fluid perfusion and mechanical compression, can enhance osteogenic differentiation of mesenchymal stem cells and bone cells within tissue engineering ... -
Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold
(2011-11)Stem cell transplantation has been suggested as a treatment for myocardial infarction, but clinical studies have yet to demonstrate conclusive, positive effects. This may be related to poor survival of the transplanted ... -
A review of Lean adoption in the Irish MedTech industry
(MDPI, 2022-02-17)There have been many literature reviews carried out on Lean implementation in larger organisations with specific focus on the automobile industry. Lean implementation in the medical device industry has not been extensively ... -
Revisiting Ishikawa's original seven basic tools of quality control: A global study and some new insights
(Institute of Electrical and Electronics Engineers (IEEE), 2021-07-26)The purpose of this global study is to investigate the validity of Dr. Ishikawa’s statement that “95% of problems in processes can be solved using the 7 Quality Control (QC) tools” in organizations. An online survey ... -
The role of integrin αVβ3 in osteocyte mechanotransduction
(Elsevier, 2014-11-10)Recent in vivo studies have proposed that integrin alpha(v)beta(3) attachments between osteocyte cell processes and the extracellular matrix may facilitate mechanosensation in bone. However the role of these attachments ... -
Selective laser sintering of hydroxyapatite/poly-epsilon-caprolactone scaffolds
(2010)Selective laser sintering (SLS) enables the fabrication of complex geometries with the intricate and controllable internal architecture required in the field of tissue engineering. In this study hydroxyapatite and ... -
Simulation of the Mechanical Response of Cells on Micropost Substrates
(American Society of Mechanical Engineers, 2013-09-20)Experimental studies where cells are seeded on micropost arrays in order to quantify their contractile behavior are becoming increasingly common. Interpretation of the data generated by this experimental technique is ... -
Single Cyclized Molecule Structure from RAFT Homopolymerization of Multi-vinyl Monomers
(2012)We explore a kinetically controlled strategy to suppress the gelation in the homopolymerization of multi-vinyl monomers (MVMs) via RAFT polymerization. We report the generation of 3D single cyclized polymer structures from ... -
Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery
(American Chemical Society, 2012-02-12)The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure has a significant effect on their transfection efficacy. The 3D branched polymeric ... -
Six Sigma application in an Irish meat processing plant to improve process yields
(Emerald, 2023-05-22)This study aims to utilise Six Sigma in an Irish-based red meat processor to reduce process variability and improve yields. This is a case study within an Irish meat processor where the structured Define, Measure, Analyse, ... -
Stability enhancement of an atomic force microscope for long-term force measurement including cantilever modification for whole cell deformation
(2012)Atomic force microscopy (AFM) is widely used in the study of both morphology and mechanical properties of living cells under physiologically relevant conditions. However, quantitative experiments on timescales of minutes ...