Browsing Biomedical Engineering (Scholarly Articles) by Title
Now showing items 55-74 of 85
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Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells
(Elsevier ScienceDirect, 2012-06-21)Numerous in-vitro studies have established that cells react to their physical environment and to applied mechanical loading. However, the mechanisms underlying such phenomena are poorly understood. Previous modelling of ... -
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
(Elsevier, 2014-02-11)Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ... -
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
(AO Research Institute Davos, 2016-05-26)Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ... -
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
(Elsevier, 2013-07-18)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding density have been shown to regulate osteoblast ... -
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
(AO Research Institute Davos, 2012)Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in bone receive biochemical stimuli from surrounding cells. These stimuli likely influence how MSCs differentiate to become bone precursors. ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700 °C, Part I: Literature Review
(Wiley, 2005-02-04)In the first part of this paper the results of a literature review are presented. An overview of the oxidation behaviour in air and in combustion environments of both pure MoSi2 and MoSi2 composites in the temperature range ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C
(Wiley, 2005-04-04)The topic Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C is discussed in a three part publication. In the first part of this paper a literature survey on the oxidation ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C. Part II: Initial screening of the oxidation behaviour of MoSi2 composites
(Wiley, 2005-03-01)In the first part of this paper a literature survey on the oxidation behaviour of MoSi2 and MoSi2 composites has been given. The present second part reports about the experimental results from oxidation tests with ... -
The past, present and future in scaffold-based tendon treatments
(Elsevier, 2015-04)Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ... -
A physical corrosion model for bioabsorbable metal stents
(2014)Absorbable metal stents (AMSs) are an emerging technology in the treatment of heart disease. Computational modelling of AMS performance will facilitate the development of this technology. In this study a physical corrosion ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part I: Theoretical Analysis
(2013)This paper presents a thorough analysis of potential-based and non-potential-based cohesive zone models (CZMs) under conditions of mixed-mode separation and mixed-mode over-closure. Problems are identified with the well ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part II: Finite element applications
(2013)This paper, the second of two parts, presents three novel finite element case studies to demonstrate the importance of normal-tangential coupling in cohesive zone models (CZMs) for the prediction of mixed-mode interface ... -
Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions
(Elsevier, 2020-03-04)The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can influence and control cell behaviour and function. While many studies ... -
Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions
(Springer, 2010-11)Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, ... -
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer, 2014-11-15)Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ... -
Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture
(AO Research Institute Davos, 2016-07-19)Bone marrow contains a multitude of mechanically sensitive cells that may participate in mechanotransduction. Primary cilia are sensory organelles expressed on mesenchymal stem cells (MSCs), osteoblasts, osteocytes, and ... -
Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures
(Springer Verlag, 2016-06)Recent studies have shown that mechanical stimulation, in the form of fluid perfusion and mechanical compression, can enhance osteogenic differentiation of mesenchymal stem cells and bone cells within tissue engineering ... -
Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold
(2011-11)Stem cell transplantation has been suggested as a treatment for myocardial infarction, but clinical studies have yet to demonstrate conclusive, positive effects. This may be related to poor survival of the transplanted ... -
The role of integrin αVβ3 in osteocyte mechanotransduction
(Elsevier, 2014-11-10)Recent in vivo studies have proposed that integrin alpha(v)beta(3) attachments between osteocyte cell processes and the extracellular matrix may facilitate mechanosensation in bone. However the role of these attachments ... -
Selective laser sintering of hydroxyapatite/poly-epsilon-caprolactone scaffolds
(2010)Selective laser sintering (SLS) enables the fabrication of complex geometries with the intricate and controllable internal architecture required in the field of tissue engineering. In this study hydroxyapatite and ...