Browsing Biomedical Engineering (Scholarly Articles) by Title
Now showing items 1-20 of 112
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An actuatable soft reservoir modulates host foreign body response
(American Association for the Advancement of Science, 2019-08-28)The performance of indwelling medical devices that depend on an interface with soft tissue is plagued by complex, unpredictable foreign body responses. Such devices—including breast implants, biosensors, and drug delivery ... -
Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels
(SAGE Publications, 2018-10-25)Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical ... -
Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis
(Biophysical Society, 2015-04-07)Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical environment of bone cells and may thereby initiate a mechanobiological response. It has proved challenging to characterize the ... -
Applying Lean Six Sigma methodology to a pharmaceutical manufacturing facility: A case study
(MDPI, 2021-03-20)This research examines a case study on the implementation of an effective approach to advanced Lean Six Sigma problem-solving within a pharmaceutical manufacturing site that manufactures acetaminophen (paracetamol containing ... -
Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
(Wiley, 2013-12-03)Bone continuously adapts its internal structure to accommodate the functional demands of its mechanical environment. This process is orchestrated by a network of mechanosensitive osteocytes that respond to external ... -
Barriers and enablers for continuous improvement methodologies within the Irish pharmaceutical industry
(MDPI, 2021-12-30)This study aims to investigate the barriers that exist when implementing continuous improvement methodologies, such as Lean Six Sigma (LSS), within the Irish Pharma industry. The main finding of this study is that 45% of ... -
A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
(The Royal Society, 2011-11)Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ... -
Biomodels of bone: a review
(Springer, 2005)In this paper, a definition of a biomodel is presented, based on which different specific types of biomodels are identified, viz., virtual biomodels, computational biomodels, and physical biomodels. The paper then focuses ... -
A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction
(Elsevier, 2019-05-15)The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the ... -
Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
(Springer Verlag, 2013-06-18)Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ... -
Chondrogenic induction of mesenchymal stromal/stem cells from Wharton's jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering
(BioMed Central, 2015-12-30)Background: Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone ... -
A combined experimental-numerical approach for generating statistically equivalent fibre distributions for high strength laminated composite materials
(Elsevier, 2009-11-04)A technique is presented where actual experimental distributions, measured from a high strength carbon fibre composite, are considered in the development of a novel method to generate statistically equivalent fibre ... -
Comparing coronary stent material performance on a common geometric platform through simulated bench testing
(Elsevier ScienceDirect, 2012-03-02)Absorbable metallic stents (AMSs) are a newly emerging cardiovascular technology which has the potential to eliminate long-term patient health risks associated with conventional permanent stents. AMSs developed to date ... -
A comparison of assisted human reproduction (AHR) regulation in Ireland with other developed countries
(BMC Part of Springer Nature, 2022-03-05)Assisted human reproduction (AHR) treatment is not regulated in Ireland although it has been practised since 1987. Thus, Ireland is one of the only European countries without any form of AHR specific regulation. This ... -
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
(Elsevier, 2015-01-14)Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the ... -
Conceptualizing Industry 4.0 readiness model dimensions: an exploratory sequential mixed-method study
(Emerald, 2021-07-16)Purpose Organizations use Industry 4.0 readiness models to evaluate their preparedness prior to the implementation of Industry 4.0. Though there are many studies on Industry 4.0 readiness models, the dimensions of readiness ... -
Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions
(Elsevier, 2014-11-27)We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces ... -
A critical evaluation and measurement of organisational readiness and adoption for continuous improvement within a medical device manufacturer
(Taylor and Francis Group, 2022-05-24)This research aims to assess the organisational readiness and maturity of continuous improvement (CI) deployment in a medical device manufacturer. A single case study approach was used, in an Irish medical device company ... -
Critical failure factors for continuous improvement methodologies in the Irish MedTech industry
(Emerald, 2022-03-10)The main objective of this study is to investigate what are the critical success factors that exist for continuous improvement (CI) methodology deployment in the Irish medical technology (MedTech) industry. The research ...