Browsing Biomedical Engineering (Scholarly Articles) by Title
Now showing items 6-25 of 95
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A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
(The Royal Society, 2011-11)Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ... -
Biomodels of bone: a review
(Springer, 2005)In this paper, a definition of a biomodel is presented, based on which different specific types of biomodels are identified, viz., virtual biomodels, computational biomodels, and physical biomodels. The paper then focuses ... -
A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction
(Elsevier, 2019-05-15)The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the ... -
Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
(Springer Verlag, 2013-06-18)Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ... -
Chondrogenic induction of mesenchymal stromal/stem cells from Wharton's jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering
(BioMed Central, 2015-12-30)Background: Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone ... -
A combined experimental-numerical approach for generating statistically equivalent fibre distributions for high strength laminated composite materials
(Elsevier, 2009-11-04)A technique is presented where actual experimental distributions, measured from a high strength carbon fibre composite, are considered in the development of a novel method to generate statistically equivalent fibre ... -
Comparing coronary stent material performance on a common geometric platform through simulated bench testing
(Elsevier ScienceDirect, 2012-03-02)Absorbable metallic stents (AMSs) are a newly emerging cardiovascular technology which has the potential to eliminate long-term patient health risks associated with conventional permanent stents. AMSs developed to date ... -
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
(Elsevier, 2015-01-14)Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the ... -
Conceptualizing Industry 4.0 readiness model dimensions: an exploratory sequential mixed-method study
(Emerald, 2021-07-16)Purpose Organizations use Industry 4.0 readiness models to evaluate their preparedness prior to the implementation of Industry 4.0. Though there are many studies on Industry 4.0 readiness models, the dimensions of readiness ... -
Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions
(Elsevier, 2014-11-27)We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces ... -
Design and manufacturing of customised maxillofacial prostheses.
(Elsevier, 2003-04-28)Customised implants created by Computer-Assisted Surgery (CAS) techniques and used in maxillofacial reconstruction indicate improved outcomes over conventional techniques. ‘‘Non-functional’’ multistaged procedures are ... -
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
(Wiley, 2015-08-12)Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ... -
DNA Immobilization and Detection on Cellulose Paper using a Surface Grown Cationic Polymer via ATRP
(American Chemical Society, 2012-02-02)Cationic polymers with various structures have been widely investigated in the areas of medical diagnostics and molecular, biology because of their unique binding properties and capability to interact with biological ... -
Does making method of alginate hydrogel influence the chondrogenic differentiation of human mesenchymal stem cells?
(Scientific Research Publishing, 2012-10)To overcome cartilage injury, strategies have been developed in the last few years based on tissue engineering to rebuild the defects. Cartilage engineering is principally based on three main biological factors: cells ... -
The effect of grain orientation on fretting fatigue plasticity and life prediction
(Elsevier ScienceDirect, 2014)A study on crystal and J2J2 plasticity prediction of fretting fatigue is presented, using a microstructure-sensitive fatigue parameter for crystal plasticity crack nucleation and a critical-plane (multiaxial) fatigue ... -
Effect of hydroxyapatite on biodegradable scaffolds fabricated by SLS
(Trans Tech Publications Ltd., 2009)Selective laser sintering (SLS) has the potential to fabricate bioresorbable polymer / ceramic composite scaffolds with pre-designed external and internal architecture that can be used for bone tissue engineering applications. ... -
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair
(Elsevier, 2012-06-25)The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. ... -
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society Publishing, 2012-07-18)The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ... -
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
(Biophysical Society, 2015-04-07)Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ...