Browsing CÚRAM Centre for Research in Medical Devices by Title

Now showing items 1-20 of 45

    • Advancements and challenges in multidomain multicargo delivery vehicles 

      Pugliese, Eugenia; Coentro, João Q.; Zeugolis, Dimitrios I. (Wiley, 2018-02-15)
      Reparative and regenerative processes are well‐orchestrated temporal and spatial events that are governed by multiple cells, molecules, signaling pathways, and interactions thereof. Yet again, currently available ...

    • Analysis of a poly(ε-decalactone)/silver nanowire composite as an electrically conducting neural interface biomaterial 

      Krukiewicz, Katarzyna; Fernandez, Jorge; Skorupa, Małgorzata; Więcławska, Daria; Poudel, Anup; Sarasua, Jose-Ramon; Quinlan, Leo R.; Biggs, Manus J. P. (BMC (part of Springer Nature), 2019-04-15)
      Advancement in polymer technologies, facilitated predominantly through chemical engineering approaches or through the identification and utilization of novel renewable resources, has been a steady focus of biomaterials ...

    • Applicability of FTIR-ATR method to measure carbonyls in blood plasma after physical and mental stress 

      Bujok, Jolanta; Gąsior-Głogowska, Marlena; Marszałek, Michał; Trochanowska-Pauk, Natalia; Zigo, František; Pavľak, Alexander; Komorowska, Małgorzata; Walsk, Tomasz (Hindawi, 2019-03-26)
      Introduction. Oxidative stress is a state of imbalance between the production of reactive oxygen species and antioxidant defenses. It results in the oxidation of all cellular elements and, to a large extent, proteins, ...

    • Automation, monitoring, and standardization of cell product manufacturing 

      Doulgkeroglou, Meletios-Nikolaos; Di Nubila, Alessia; Niessing, Bastian; König, Niels; Schmitt, Robert H.; Damen, Jackie; Szilvassy, Stephen J.; Chang, Wing; Csontos, Lynn; Louis, Sharon; Kugelmeier, Patrick; Ronfard, Vincent; Bayon, Yves; Zeugolis, Dimitrios I. (Frontiers Media, 2020-07-14)
      Although regenerative medicine products are at the forefront of scientific research, technological innovation, and clinical translation, their reproducibility and large-scale production are compromised by automation, ...

    • Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties 

      Joyce, Kieran; Fabra, Georgina Targa; Bozkurt, Yagmur; Pandit, Abhay (Springer Nature, 2021-03-19)
      Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, ...

    • Biophysics rules the cell culture but has yet to reach the clinic: Why is that? 

      Guillaumin, Salomé; Sallent, Ignacio; Zeugolis, Dimitrios I. (Lippincott, Williams & Wilkins, 2017-07)
      Musculoskeletal injuries are the leading cause of physical disability worldwide, with associated annual direct and indirect healthcare expenditure in excess of $874 billion in the United States alone.1 Current treatments ...

    • Characterization of the ‘White’ appearing clots that cause acute ischemic stroke 

      Mereuta, Oana Madalina; Rossi, Rosanna; Douglas, Andrew; Molina Gil, Sara; Fitzgerald, Seán; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Eric; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; O'Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David F.; Szikora, Istvan; Rentzos, Alexandros; Tatlisumak, Turgut; Thornton, John; Doyle, Karen M. (Elsevier, 2021-09-28)
      Objectives Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the ...

    • The chemistry and topography of stabilized and functionalized graphene oxide coatings 

      Awaja, Firas; Tripathi, Manoj; Wong, Tsz‐Ting; O'Brien, Timothy; Speranza, Giorgio (Wiley, 2018-08-01)
      Graphene oxide (GO) thin films and coatings are regarded as superior in quality to other materials especially for biomedical applications. However, the lack of stability and understanding of their structure and defects ...

    • Chirality-sorted carbon nanotube films as high capacity electrode materials 

      Krukiewicz, Katarzyna; Krzywiecki, Maciej; Biggs, Manus J. P.; Janas, Dawid (Royal Society of Chemistry, 2018-08-30)
      Carbon nanomaterials show great promise for a wide range of applications due to their excellent physicochemical and electrical properties. Since their discovery, the state-of-the-art has expanded the scope of their application ...

    • The collagen suprafamily: From biosynthesis to advanced biomaterial development 

      Sorushanova, Anna; Delgado, Luis M.; Wu, Zhuning; Shologu, Naledi; Kshirsagar, Aniket; Raghunath, Rufus; Mullen, Anne M.; Bayon, Yves; Pandit, Abhay; Raghunath, Michael; Zeugolis, Dimitrios I. (Wiley, 2018-08-20)
      Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their ...

    • Concept design of a new portable medical device for lymphedema monitoring: A EIT Health ClinMed Summer School project 

      Tisaire, Jordi; Rodrigo, Elena; Ribeiro, Sofia; Ricci, Mariachiara; Cuellar, Juan; Zeugolis, Dimitrios I.; Bayon, Yves; Rocha, Isabel (SciTePress, 2019)
      Lymphedema is a chronic and progressive condition derived from impaired lymphatic system function. Lymphedema is incurable, progressive, disfiguring, disabling and has adverse psychosocial effects. Upper extremity lymphedema ...

    • Current and upcoming therapies to modulate skin scarring and fibrosis 

      Coentro, João Q.; Pugliese, Eugenia; Hanley, Geoffrey; Raghunath, Michael; Zeugolis, Dimitrios I. (Elsevier, 2018-08-30)
      Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response ...

    • Design and characterization of a three-layer collagen-based scaffold to modulate BMSC behaviour for enthesis regeneration 

      Pugliese, Eugenia; Zeugolis, Dimitrios I. (Wiley, 2019-04-08)
      The enthesis is a specialised tissue interface between tendon and bone, essential for adequate force transmission. Following injuries and surgical repair, the enthesis is often not re-established and traditionally used ...

    • Design and characterization of synthetic biodegradable films for soft tissue engineering 

      Ribeiro, Sofia; Fernandes, Emanuel; Gomes, Manuela; Reis, Rui; Bayon, Yves; Zeugolis, Dimitrios I. (SciTePress, 2019)
      To repair soft tissue, it is vital to ensure that the biomaterial is able to mimic the complex elasticity of the native tissue. Substrate stiffness has a huge influence on cell physiology and behaviour. The present study ...

    • The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture 

      Tsiapalis, Dimitrios; Rana, Shubhasmin; Doulgkeroglo, Meletios; Kearns, Stephen; Kelly, Jack; Bayon, Yves; Zeugolis, Dimitrios I. (Elsevier Academic Press, 2019-11-30)
      Tendon injuries continuously rise, and regeneration is not only slow, but also limited due to the poor endogenous healing ability of the tendon tissue. Tissue grafts constitute the clinical gold standard treatment for ...

    • Electric field stimulation for tissue engineering applications 

      Ryan, Christina N. M.; Doulgkeroglou, Meletios N.; Zeugolis, Dimitrios I. (BMC (part of Springer Nature), 2021-01-05)
      Electric fields are involved in numerous physiological processes, including directional embryonic development and wound healing following injury. To study these processes in vitro and/or to harness electric field stimulation ...

    • Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: Cytocompatibility and electrochemical studies 

      Krukiewicz, Katarzyna; Kowalik, Agnieszka; Czerwinska-Glowka, Dominika; Biggs, Manus J. P. (Elsevier, 2019-02-06)
      Conducting polymers have been extensively reported as promising coating materials for applications involving interactions with electrically excitable tissues. Specifically, metal electrodes functionalized with conducting ...

    • Empowering translation of new ideas - A EIT Health ClinMed Summer School overview 

      Ribeiro, Sofia; Ricci, Mariachiara; Von Der Lieth, Albert; Bayon, Yves; Zeugolis, Dimitrios I.; Pelayo, Sylvia; Marque, Isabelle; Pazart, Lionel (SciTePress, 2019)
      Translational research training is crucial to convert academic research ideas into efficient real-life solutions. In this paper a summer school supported by EIT Health is presented. Its main goal is to integrate clinical ...

    • Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions 

      Krukiewicz, Katarzyna; Kruk, Aleksandra; Turczyn, Roman (Elsevier, 2018-09-08)
      Conducting polymers are versatile and robust materials that have recently become attractive as controlled drug delivery systems. Possessing ion exchangeable properties, they can serve as carriers for numerous biologically ...

    • Fibrin as a scaffold for delivery of GDNF overexpressing stem cells to the adult rat brain 

      Moloney, Teresa C.; Kulkarni, Mangesh; Ní Fhlathartaigh1, Mary; Abhay, Pandit; Dowd, Eilís (2017-04-05)
      Treatment of neurodegenerative disease is entering a new era where direct intracerebral delivery of therapeutic factors aims to restore normality to dysfunctional circuits. Cell-based therapeutic approaches, where virally ...