Automation, monitoring, and standardization of cell product manufacturing
Di Nubila, Alessia
Schmitt, Robert H.
Szilvassy, Stephen J.
Zeugolis, Dimitrios I.
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Doulgkeroglou, Meletios-Nikolaos, Di Nubila, Alessia, Niessing, Bastian, König, Niels, Schmitt, Robert H., Damen, Jackie, Szilvassy,Stephen J., Chang,Wing, Csontos,Lynn, Louis,Sharon, Kugelmeier,Patrick, Ronfard,Vincent, Bayon,Yves, Zeugolis, Dimitrios I. (2020). Automation, Monitoring, and Standardization of Cell Product Manufacturing. Frontiers in Bioengineering and Biotechnology, 8(811). doi:10.3389/fbioe.2020.00811
Although regenerative medicine products are at the forefront of scientific research, technological innovation, and clinical translation, their reproducibility and large-scale production are compromised by automation, monitoring, and standardization issues. To overcome these limitations, new technologies at software (e.g., algorithms and artificial intelligence models, combined with imaging software and machine learning techniques) and hardware (e.g., automated liquid handling, automated cell expansion bioreactor systems, automated colony-forming unit counting and characterization units, and scalable cell culture plates) level are under intense investigation. Automation, monitoring and standardization should be considered at the early stages of the developmental cycle of cell products to deliver more robust and effective therapies and treatment plans to the bedside, reducing healthcare expenditure and improving services and patient care.
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