Biophysics rules the cell culture but has yet to reach the clinic: Why is that?
Date
2017-07Author
Guillaumin, Salomé
Sallent, Ignacio
Zeugolis, Dimitrios I.
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Recommended Citation
Guillaumin, Salomé, Sallent, Ignacio, & Zeugolis, Dimitrios I. (2017). Biophysics Rules the Cell Culture but Has Yet to Reach the Clinic: Why Is That? JAAOS - Journal of the American Academy of Orthopaedic Surgeons, 25(7), e144-e147. doi:10.5435/jaaos-d-17-00324
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Abstract
Musculoskeletal injuries are the leading cause of physical disability worldwide, with associated annual direct and indirect healthcare expenditure in excess of $874 billion in the United States alone.1 Current treatments are predominantly based on tissue grafts (autografts are preferred)2,3 and biomaterials.4,5 Given that the former are associated with scarce availability, insufficient remodeling, and adverse immune reactions,6-8 and the latter with substandard stability, poor biologic response, and foreign body response,9-11 their clinical suitability has been questioned and gave rise to the field of cell-based therapies.12