CÚRAM Centre for Research in Medical Devices
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Characterization of the ‘White’ appearing clots that cause acute ischemic stroke
(Elsevier, 2021-09-28)Objectives Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the ... -
Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy
(BMJ Publishing Group, 2021-05-11)Background Several animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following ... -
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties
(Springer Nature, 2021-03-19)Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, ... -
High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke
(BMJ Publishing Group, 2020-12-23)Background: Characterization of acute ischemic stroke (AIS) clots has typically focused on two dimensional histological analysis of the thrombus. The three dimensional (3D) architecture and distribution of components ... -
Automation, monitoring, and standardization of cell product manufacturing
(Frontiers Media, 2020-07-14)Although regenerative medicine products are at the forefront of scientific research, technological innovation, and clinical translation, their reproducibility and large-scale production are compromised by automation, ... -
Electric field stimulation for tissue engineering applications
(BMC (part of Springer Nature), 2021-01-05)Electric fields are involved in numerous physiological processes, including directional embryonic development and wound healing following injury. To study these processes in vitro and/or to harness electric field stimulation ... -
A glycotherapeutic approach to functionalize biomaterials-based systems
(Wiley, 2020-03-18)In addition to being one of the primary building block materials of living cells, glycans are also favorable candidates for therapeutic applications. In the mid-20th century, the progress of glycans in the drug discovery ... -
The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture
(Elsevier Academic Press, 2019-11-30)Tendon injuries continuously rise, and regeneration is not only slow, but also limited due to the poor endogenous healing ability of the tendon tissue. Tissue grafts constitute the clinical gold standard treatment for ... -
Design and characterization of a three-layer collagen-based scaffold to modulate BMSC behaviour for enthesis regeneration
(Wiley, 2019-04-08)The enthesis is a specialised tissue interface between tendon and bone, essential for adequate force transmission. Following injuries and surgical repair, the enthesis is often not re-established and traditionally used ... -
Design and characterization of synthetic biodegradable films for soft tissue engineering
(SciTePress, 2019)To repair soft tissue, it is vital to ensure that the biomaterial is able to mimic the complex elasticity of the native tissue. Substrate stiffness has a huge influence on cell physiology and behaviour. The present study ... -
Concept design of a new portable medical device for lymphedema monitoring: A EIT Health ClinMed Summer School project
(SciTePress, 2019)Lymphedema is a chronic and progressive condition derived from impaired lymphatic system function. Lymphedema is incurable, progressive, disfiguring, disabling and has adverse psychosocial effects. Upper extremity lymphedema ... -
Empowering translation of new ideas - A EIT Health ClinMed Summer School overview
(SciTePress, 2019)Translational research training is crucial to convert academic research ideas into efficient real-life solutions. In this paper a summer school supported by EIT Health is presented. Its main goal is to integrate clinical ... -
Current and upcoming therapies to modulate skin scarring and fibrosis
(Elsevier, 2018-08-30)Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response ... -
The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents
(IOP Publishing, 2020-02-26)Cellular therapies play an important role in tendon tissue engineering, with tenocytes being the most prominent and potent cell population available. However, for the development of a rich extracellular matrix tenocyte-assembled ... -
Preparation and characterization of tissue surrogates rich in extracellular matrix using the principles of macromolecular crowding
(Humana Press, 2019-03)Tissue engineering by self-assembly allows for the fabrication of living tissue surrogates by taking advantage of the cell's inherent ability to produce and deposit tissue-specific extracellular matrix. However, the long ... -
The collagen suprafamily: From biosynthesis to advanced biomaterial development
(Wiley, 2018-08-20)Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their ... -
Hypoxia preconditioning of bone marrow mesenchymal stem cells before implantation in orthopaedics
(Lippincott, Williams & Wilkins, 2019-12-01)[No abstract available] -
Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs
(Elsevier, 2019-06-19)The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ... -
Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
(Springer Verlag, 2018-07-31)The 4th Translational Research Symposium (TRS) was organised at the annual meeting of the European Society for Biomaterials (ESB) 2017, Athens, Greece, with a focus on ‘Academia—Industry Clusters of Research for Innovation ... -
Low resistance, highly corrugated structures based on poly(3,4-ethylenedioxythiophene) doped with a d-glucopyranoside-derived ionic liquid
(Elsevier, 2019-12-02)Conjugated polymers have gained significant interest as highly conducting organic materials with versatile surface morphology. In this study, we demonstrate that the electrodeposition of poly(3,4-ethylenedioxythiophene), ...