The collagen suprafamily: From biosynthesis to advanced biomaterial development
Delgado, Luis M.
Mullen, Anne M.
Zeugolis, Dimitrios I.
MetadataShow full item record
This item's downloads: 2432 (view details)
Cited 158 times in Scopus (view citations)
Sorushanova, Anna, Delgado, Luis M., Wu, Zhuning, Shologu, Naledi, Kshirsagar, Aniket, Raghunath, Rufus, Mullen, Anne M., Bayon, Yves, Pandit, Abhay, Raghunath, Michael, Zeugolis, Dimitrios I. (2019). The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development. Advanced Materials, 31(1), 1801651. doi:10.1002/adma.201801651
Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their respective structures, conformation, and biosynthesis is provided. The advances and shortfalls of various collagen preparations (e.g., mammalian/marine extracted collagen, cell-produced collagens, recombinant collagens, and collagen-like peptides) and crosslinking technologies (e.g., chemical, physical, and biological) are then critically discussed. Subsequently, an array of structural, thermal, mechanical, biochemical, and biological assays is examined, which are developed to analyze and characterize collagenous structures. Lastly, a comprehensive review is provided on how advances in engineering, chemistry, and biology have enabled the development of bioactive, 3D structures (e.g., tissue grafts, biomaterials, cell-assembled tissue equivalents) that closely imitate native supramolecular assemblies and have the capacity to deliver in a localized and sustained manner viable cell populations and/or bioactive/therapeutic molecules. Clearly, collagens have a long history in both evolution and biotechnology and continue to offer both challenges and exciting opportunities in regenerative medicine as nature's biomaterial of choice.
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland
Showing items related by title, author, creator and subject.
Delgado, Luis Maria (2018-03-07)Collagen-based devices are frequently associated with foreign body response. Although several pre- (e.g. species, state of animal, tissue, isolation protocol) and post- (e.g. cross-linking, scaffold architecture, sterilisation) ...
Acetic acid and pepsin result in high yield, high purity and low macrophage response collagen for biomedical applications Delgado, Luis M; Shologu, Naledi; Fuller, Kieran; Zeugolis, Dimitrios I. (IOP Publishing, 2017-08-02)Collagen based devices are frequently associated with foreign body response. Although several pre(e.g. species, state of animal, tissue) and post-(e.g. cross-linking, scaffold architecture) extraction method factors have ...
Development and characterisation of compressed, macro-porous and collagen-coated poly-ε-caprolactone electrospun meshes Fuller, Kieran P. (NUI Galway, 2019-02-25)Electrospun scaffolds are utilised in a diverse spectrum of clinical targets, with an ever-increasing quantity of work progressing to clinical studies and commercialisation. However, the very dense architecture and the low ...