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Now showing items 111-120 of 137
The role of the liver X receptor in mitotane therapy in adrenocortical carcinoma
(NUI Galway, 2020-08-12)
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. The Liver X Receptor α (LXRα) is highly expressed in the adrenal cortex, and functions to regulate cholesterol and lipid ...
Medical devices for the minimally invasive delivery of therapeutic cargo for the prevention of heart failure
(NUI Galway, 2020-11-10)
Therapeutic advances are increasing the number of patients that survive cardiac disease
such as a myocardial infarction, however, current treatments do not fully stop the
development of heart failure. Advanced therapeutic ...
Exploration of the opioidergic system in the olfactory bulbectomized rat model of depression
(NUI Galway, 2020-02-27)
In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ...
Epigenetic regulation of NOD-like receptor activity and expression
(NUI Galway, 2018-11-19)
NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ...
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2020-03-05)
Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ...
Immunogenicity of allogeneic mesenchymal stem cells
(2016-10-20)
Allogeneic mesenchymal stem cells (allo-MSC) are a promising “off-the-shelf” therapy and are often cited as failing to elicit anti-donor immune responses. Intra-muscular (IM) administration may be the optimal route for ...
Neuroanatomical dysconnectivity in bipolar disorder
(2016-10-13)
Bipolar Disorder (BD) is a major psychotic illness characterized by cyclic mood dysregulation. The dysconnectivity hypothesis suggests that psychotic illnesses arise not from regionally specific focal pathophysiology, but ...
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
(NUI Galway, 2018-12-14)
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ...
Regulation of cell fate by microRNAs during unfolded protein response and its role in cancer
(NUI Galway, 2018-12-20)
The endoplasmic reticulum (EnR) stress is a common phenomenon in various cancers such as breast, colorectal, skin and hepatocellular carcinoma. Several pathophysiological events (e.g., radiation, aneuploidy, oncogenic ...
Human endogenous retrovirus K (HERV-K) in prostate cancer
(2016-08-08)
Millions of years of infection by viral agents have left their mark on the human genome in the form of human endogenous retroviruses (HERVs). These retroelements integrated into our germline, became subject to Mendelian ...