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Regulation of fear, anxiety and cognition in the presence or absence of pain by peroxisome proliferator-activated receptors
(NUI Galway, 2019-06-07)
Fear/anxiety and pain modulate one another reciprocally, but the neurobiological mechanisms that underlie this interaction are not completely understood. Fear-conditioned analgesia (FCA) is pain suppression upon exposure ...
Factors influencing diagnosis and outcome in HER2 receptor positive breast cancer
(NUI Galway, 2019-02-22)
Introduction
About 30% of breast cancers are HER2 receptor positive, these breast cancers traditionally had a poor prognosis but the introduction of targeted anti-HER2 therapy (Trastuzumab) has resulted in a vast improvement ...
Mechanistic insights into novel cellular therapy strategies for the treatment of corneal allograft rejection
(NUI Galway, 2019-02-14)
It has previously been demonstrated by our lab that tolerogenic dendritic cells (tDCs) prolong corneal allograft survival. This study revealed that tDCs had significantly higher levels of sialic acid on the cell surface ...
Therapeutic targets for duchenne muscular dystrophy
(NUI Galway, 2019-07-05)
Duchenne Muscular Dystrophy (DMD) is a progressive X-linked fatal muscle degenerative disorder caused by the absence of the sarcolemmal associated dystrophin-glycoprotein complex (DGC) that connects the intracellular ...
Assessment of the consequences of gestational SSRI antidepressant exposure in the rat
(NUI Galway, 2019-10-08)
Although the most common psychotropic drugs prescribed in pregnancy are selective serotonin reuptake inhibitor (SSRI) antidepressants, their health impact on the resultant offspring is largely unknown due to the ethical ...
Triple negative breast cancer: outcomes, subtypes and implications for treatment
(NUI Galway, 2019-11-30)
Triple negative breast cancer (TNBC) is a heterogeneous subtype representing 15-20% of all breast cancers and is associated with a poor prognosis, despite the advances made in other breast cancer subtypes. TNBC is defined ...
The role of the endogenous opioid system in social motivation and cognition in the valproic acid model of social impairment
(NUI Galway, 2019-11-11)
Positive social interactions and successful relationships are important for physical and mental health, and have been shown to elicit beneficial effects on multiple physiological systems and bodily function. Impairments ...
Measuring and improving patient safety in general practice in Ireland
(NUI Galway, 2019-11-15)
Due to the large volume of primary care consultations and increasing patient complexity, there is substantial potential for unintentional patient harm. Measuring and monitoring of safety is essential to identify the ...
Split luciferase reporters of apoptosome formation: a bio-tool to identify new drug-like molecules
(NUI Galway, 2019-12-03)
Formation of apoptosome, a key multiprotein complex in mitochondrial-mediated apoptosis, is an essential step during normal development and deregulation of this event is associated with pathological conditions. The apoptosome ...
The Bangladesh National Blindness and Low Vision Survey - Identification of prevalence, causes and the need for eye care services
(NUI Galway, 2019-10-15)
Background:
Bangladesh is a densely populated, impoverished country in South Asia with inadequate health service provision for a variety of diseases including treatable ocular conditions. The aims of this comprehensive ...