During this work, I examined a cohort of patients with severe and complicated obesity undergoing a milk-based intensive weight management programme, examining changes in various traits in the short and medium term. Firstly, ...

Stromal cells have long been studied for their putative role in maintaining tissue homeostasis, driving tissue remodeling processes during injury, and modulating inflammation by synergizing with immune cells. Studying ...

Osteoarthritis (OA) is the most common degenerative condition affecting whole joints and causing pain and cartilage degeneration, particularly in the elderly population. Inflammation of the synovium is now recognised as ...

Autism spectrum disorders (ASD), include a group of heterogeneous neurodevelopmental disorders (NDDs) characterized by impaired social interaction, and communication with restricted patterns of behaviour. The aetiology ...

Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the tumour and bypass the host immune system. Extracellular Vesicles (EVs) are thought to be a fingerprint of the parent cell and therefore MSC-EVs ...

Caspases are the core compartments of programmed cell death. Caspases also play non apoptotic roles in cell proliferation, migration, differentiation, and immunity. During myoblast differentiation, caspase-2, -9 and -3 are ...

Islet encapsulation devices can induce a Foreign Body Response (FBR) and the formation of a hardened avascular fibrotic capsule. This FBR is heightened when the device features a smooth surface as fibrous tissue is unable ...

Autism is a neurodevelopmental disorder which affects 1 in 54 children. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of autism. Similarly, prenatal exposure of rodents ...

Background: Bronchiectasis is a chronic lung disease associated with significant morbidity and mortality, escalating public health costs and profound reductions in health-related quality of life (QoL). Comorbidity is a ...

Introduction: Sepsis is a syndrome of life-threatening physiologic, pathologic, and biochemical abnormalities resulting from infection 1. The host immune response, specifically the loss of immune homeostasis induced by ...