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Cartilage repair in a rabbit model: Development of a novel subchondral defect and assessment of early cartilage repair using a rabbit mesenchymal stem cell seeded scaffold
(2018-02-14)
Purpose: To develop a subchondral defect in a rabbit model and assess cartilage repair using a mesenchymal stem cell-seeded scaffold.
Materials and Methods: To achieve this goal, a bovine explant model and two pilot ...
Pro-inflammatory cytokine licensing as a strategy to enhance the efficacy of syngeneic mesenchymal stem cells for corneal transplantation
(NUI Galway, 2018-05-11)
It has previously been demonstrated by our lab that allogeneic MSCs prolong corneal allograft survival however syngeneic MSCs fail to do so. The aim of this study was to investigate if pre-treating syngeneic MSCs with ...
Semantic modelling of protein-protein interactions, their prediction and evaluation
(2018-02-23)
The amount of biomedical data produced by DNA-sequencing, by curated knowledge on disease mechanisms and treatments, by results from biochemical and pharmaceutical research and by many other data generation studies is ...
Bone marrow stromal cell transplantation ameliorates cytopenias caused by depletion of FAP-α expressing cells
(NUI Galway, 2018-05-03)
Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflammatory diseases as phase 3 clinical trials have demonstrated. However, the en-dogenous roles of stromal cells (SSCs) are ...
The potential of injectable collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2018-10-04)
Extensive pre-clinical and clinical assessment has shown that, when transplanted into the Parkinsonian brain, primary dopaminergic neurons can survive, integrate with the host system, produce dopamine and provide functional ...
Trends in the incidence and outcomes of end stage kidney disease from specific causes and the ability of measures of kidney function to predict mortality in community dwelling individuals
(NUI Galway, 2018-03-09)
Summary of Contents
There are two broad themes in this research thesis. The first is an exploration of the ability of measures of kidney function and urinary protein excretion to predict death based on non-parametric ...
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
(NUI Galway, 2018-04-13)
There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ...
A role for nanor in early zebrafish development and validation of a neurotoxic zebrafish model of Parkinson’s disease
(NUI Galway, 2018-04-06)
Zebrafish are a versatile experimental model which have progressed the fields of many research areas through both genetic and pharmacological studies. In this thesis I studied a novel zygotic gene, nanor, in zebrafish and ...
Development and evaluation of an assessment tool for identification of elements of situation awareness in OSCEs in undergraduate medical curricula
(NUI Galway, 2018-07-20)
Situation awareness (SA) is recognised as an important factor in patient safety and clinical decision making in conjunction with diagnostic and therapeutic reasoning. Missed diagnosis and treatment errors have been identified ...
Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
(2018-02-05)
It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ...