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Developing and characterizing cellular models for neurodegenerative diseases.
(2016-05-13)
The focus of this work was to develop and validate in vitro cell culture models of neurodegenerative diseases, with a focus on Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease characterized ...
Pro-inflammatory cytokine licensing as a strategy to enhance the efficacy of syngeneic mesenchymal stem cells for corneal transplantation
(NUI Galway, 2018-05-11)
It has previously been demonstrated by our lab that allogeneic MSCs prolong corneal allograft survival however syngeneic MSCs fail to do so. The aim of this study was to investigate if pre-treating syngeneic MSCs with ...
Modulation of inflammatory pain in intervertebral disc degeneration: A therapeutic biomaterials approach
(2017-10-05)
Discogenic low back pain (LBP) is a very common health problem that imposes a socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the causative factors of LBP. It is mediated by an ...
Semantic modelling of protein-protein interactions, their prediction and evaluation
(2018-02-23)
The amount of biomedical data produced by DNA-sequencing, by curated knowledge on disease mechanisms and treatments, by results from biochemical and pharmaceutical research and by many other data generation studies is ...
Bone marrow stromal cell transplantation ameliorates cytopenias caused by depletion of FAP-α expressing cells
(NUI Galway, 2018-05-03)
Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflammatory diseases as phase 3 clinical trials have demonstrated. However, the en-dogenous roles of stromal cells (SSCs) are ...
Stem cell modelling for the role of NRXN1 deletion in Autism Spectrum Disorder
(NUI Galway, 2018-12-21)
Autism spectrum disorder (ASD), a multi-factorial disease, often has co-morbidity with epilepsy, which is associated with excessive neuronal firing. The pre-synaptic protein Neurexin1 (NRXN1) signals bi-directionally through ...
Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
(2017-10-10)
The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ...
Feasibility of mesenchmyal stem cells as modulators of inflammation and as a cellular model to study cartilage damage in osteoarthritis
(NUI Galway, 2020-04-10)
Osteoarthritis (OA) is the most common degenerative condition affecting whole joints and causing pain and cartilage degeneration, particularly in the elderly population. Inflammation of the synovium is now recognised as ...
Evaluation of human induced pluripotent stem cell-based cellular models for pathological investigation of genetic skeletal diseases
(NUI Galway, 2019-02-15)
The uniqueness of stem cells endows them with the capacity to be used as a valuable tool in the field of pathology, particularly the one from patients. Patient-specific cellular model can be generated by deriving donor-specific ...
In vitro, pre-clinical and commercial evaluation of a novel xeno- and serum-free culture system for production of human bone marrow derived mesenchymal stem cells for bone regeneration
(2016-10-21)
The therapeutic potential of mesenchymal stem cells (MSCs) is recognised in treating a wide range of debilitating diseases. For clinical-scale manufacturing, serum-free and xenogenic-free media formulations have been ...