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Now showing items 131-137 of 137
The role of the endogenous opioid system in social motivation and cognition in the valproic acid model of social impairment
(NUI Galway, 2019-11-11)
Positive social interactions and successful relationships are important for physical and mental health, and have been shown to elicit beneficial effects on multiple physiological systems and bodily function. Impairments ...
Novel approaches to the understanding and treatment of postoperative pain
(NUI Galway, 2019-12-06)
Postoperative pain constitutes a significant medical need. Greater understanding of the mechanisms will allow for more effective treatments. The endogenous cannabinoid (endocannabinoid) and opioid systems play a key role ...
Optogenetic investigations into the role of glutamatergic neurons of the anterior cingulate cortex in sensory and affective components of pain
(NUI Galway, 2019-11-15)
Pain consists of sensory-discriminative and affective-motivational components, which can share a reciprocal relationship. The anterior cingulate cortex (ACC) plays an important role in top-down control and the affective ...
The role of the endocannabinoid system in the affective modulation of pain
(2015-09-30)
Pain represents a major unmet clinical need and affects a large number of individuals worldwide. Numerous studies indicate a very high prevalence of chronic pain comorbid with psychiatric disorders such as anxiety and ...
Anti-inflammatory hydrogel enrichment for cell-based brain repair in Parkinson's disease
(NUI Galway, 2020-01-28)
Cell transplantation as a therapeutic approach for Parkinson’s disease has been extensively studied over the past decades. The transplantation of primary dopaminergic neurons in the degenerated striatum has shown that these ...
The neural network basis of cognitive impairment in bipolar disorder
(NUI Galway, 2020-01-22)
Background: Despite well-documented cognitive deficits that contribute to poorer quality of life in bipolar disorder (BD) and evidence of altered topology and connectivity within neural networks, little work has been done ...
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
(NUI Galway, 2020-02-04)
Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ...