Browsing Research Institutes and Centres by Author "Zeugolis, Dimitrios I."
Now showing items 1-20 of 22
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Advancements and challenges in multidomain multicargo delivery vehicles
Pugliese, Eugenia; Coentro, João Q.; Zeugolis, Dimitrios I. (Wiley, 2018-02-15)Reparative and regenerative processes are well‐orchestrated temporal and spatial events that are governed by multiple cells, molecules, signaling pathways, and interactions thereof. Yet again, currently available ... -
Automation, monitoring, and standardization of cell product manufacturing
Doulgkeroglou, Meletios-Nikolaos; Di Nubila, Alessia; Niessing, Bastian; König, Niels; Schmitt, Robert H.; Damen, Jackie; Szilvassy, Stephen J.; Chang, Wing; Csontos, Lynn; Louis, Sharon; Kugelmeier, Patrick; Ronfard, Vincent; Bayon, Yves; Zeugolis, Dimitrios I. (Frontiers Media, 2020-07-14)Although regenerative medicine products are at the forefront of scientific research, technological innovation, and clinical translation, their reproducibility and large-scale production are compromised by automation, ... -
Biophysics rules the cell culture but has yet to reach the clinic: Why is that?
Guillaumin, Salomé; Sallent, Ignacio; Zeugolis, Dimitrios I. (Lippincott, Williams & Wilkins, 2017-07)Musculoskeletal injuries are the leading cause of physical disability worldwide, with associated annual direct and indirect healthcare expenditure in excess of $874 billion in the United States alone.1 Current treatments ... -
The collagen suprafamily: From biosynthesis to advanced biomaterial development
Sorushanova, Anna; Delgado, Luis M.; Wu, Zhuning; Shologu, Naledi; Kshirsagar, Aniket; Raghunath, Rufus; Mullen, Anne M.; Bayon, Yves; Pandit, Abhay; Raghunath, Michael; Zeugolis, Dimitrios I. (Wiley, 2018-08-20)Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their ... -
Concept design of a new portable medical device for lymphedema monitoring: A EIT Health ClinMed Summer School project
Tisaire, Jordi; Rodrigo, Elena; Ribeiro, Sofia; Ricci, Mariachiara; Cuellar, Juan; Zeugolis, Dimitrios I.; Bayon, Yves; Rocha, Isabel (SciTePress, 2019)Lymphedema is a chronic and progressive condition derived from impaired lymphatic system function. Lymphedema is incurable, progressive, disfiguring, disabling and has adverse psychosocial effects. Upper extremity lymphedema ... -
Current and upcoming therapies to modulate skin scarring and fibrosis
Coentro, João Q.; Pugliese, Eugenia; Hanley, Geoffrey; Raghunath, Michael; Zeugolis, Dimitrios I. (Elsevier, 2018-08-30)Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response ... -
Design and characterization of a three-layer collagen-based scaffold to modulate BMSC behaviour for enthesis regeneration
Pugliese, Eugenia; Zeugolis, Dimitrios I. (Wiley, 2019-04-08)The enthesis is a specialised tissue interface between tendon and bone, essential for adequate force transmission. Following injuries and surgical repair, the enthesis is often not re-established and traditionally used ... -
Design and characterization of synthetic biodegradable films for soft tissue engineering
Ribeiro, Sofia; Fernandes, Emanuel; Gomes, Manuela; Reis, Rui; Bayon, Yves; Zeugolis, Dimitrios I. (SciTePress, 2019)To repair soft tissue, it is vital to ensure that the biomaterial is able to mimic the complex elasticity of the native tissue. Substrate stiffness has a huge influence on cell physiology and behaviour. The present study ... -
The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture
Tsiapalis, Dimitrios; Rana, Shubhasmin; Doulgkeroglo, Meletios; Kearns, Stephen; Kelly, Jack; Bayon, Yves; Zeugolis, Dimitrios I. (Elsevier Academic Press, 2019-11-30)Tendon injuries continuously rise, and regeneration is not only slow, but also limited due to the poor endogenous healing ability of the tendon tissue. Tissue grafts constitute the clinical gold standard treatment for ... -
Electric field stimulation for tissue engineering applications
Ryan, Christina N. M.; Doulgkeroglou, Meletios N.; Zeugolis, Dimitrios I. (BMC (part of Springer Nature), 2021-01-05)Electric fields are involved in numerous physiological processes, including directional embryonic development and wound healing following injury. To study these processes in vitro and/or to harness electric field stimulation ... -
Empowering translation of new ideas - A EIT Health ClinMed Summer School overview
Ribeiro, Sofia; Ricci, Mariachiara; Von Der Lieth, Albert; Bayon, Yves; Zeugolis, Dimitrios I.; Pelayo, Sylvia; Marque, Isabelle; Pazart, Lionel (SciTePress, 2019)Translational research training is crucial to convert academic research ideas into efficient real-life solutions. In this paper a summer school supported by EIT Health is presented. Its main goal is to integrate clinical ... -
Hypoxia preconditioning of bone marrow mesenchymal stem cells before implantation in orthopaedics
Tsiapalis, Dimitrios; Zeugolis, Dimitrios I. (Lippincott, Williams & Wilkins, 2019-12-01)[No abstract available] -
Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
De Pieri, Andrea; Ribeiro, Sofia; Tsiapalis, Dimitrios; Eglin, David; Bohner, Marc; Dubruel, Peter; Proctor, Philip; Zeugolis, Dimitrios I.; Bayon, Yves (Springer Verlag, 2018-07-31)The 4th Translational Research Symposium (TRS) was organised at the annual meeting of the European Society for Biomaterials (ESB) 2017, Athens, Greece, with a focus on ‘Academia—Industry Clusters of Research for Innovation ... -
Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs
Gaspar, Diana; Peixoto, Rita; De Pieri, Andrea; Striegl, Britta; Zeugolis, Dimitrios I.; Raghunath, Michael (Elsevier, 2019-06-19)The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ... -
Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
Kumar, Pramod; Satyam, Abhigyan; Fan, Xingliang; Collin, Estelle; Rochev, Yury; Joshi, Lokesh; Pandit, Abhay; Zeugolis, Dimitrios I. (Nature Publishing Group, 2015-03-04)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein
Abu-Rub, Mohammad T.; Zeugolis, Dimitrios I.; McMahon, Siobhan; Pandit, Abhay (Royal Society of Chemistry, 2011-01-11)The development of nerve guidance conduits is constantly evolving as the need arises for therapies for spinal cord injury. In addition to providing a path for regrowing axons to reconnect with their appropriate targets, ... -
Preparation and characterization of tissue surrogates rich in extracellular matrix using the principles of macromolecular crowding
Djalali-Cuevas, Adrian; Garnica-Galvez, Sergio; Rampin, Andrea; Gaspar, Diana; Skoufos, Ioannis; Tzora, Athina; Prassinos, Nikitas; Diakakis, Nikolaos; Zeugolis, Dimitrios I. (Humana Press, 2019-03)Tissue engineering by self-assembly allows for the fabrication of living tissue surrogates by taking advantage of the cell's inherent ability to produce and deposit tissue-specific extracellular matrix. However, the long ... -
Production and characterization of chemically cross-linked collagen scaffolds
Sallent, Ignacio; Capella-Monsonís, Héctor; Zeugolis, Dimitrios I. (Humana Press, 2019-03-07)Chemical cross-linking of collagen-based devices is used as a means of increasing the mechanical stability and control the degradation rate upon implantation. Herein, we describe techniques to produce cross-linked with ... -
Spinal cord injury in vitro: Modelling axon growth inhibition
Abu-Rub, Mohammad; McMahon, Siobhan; Zeugolis, Dimitrios I.; Pandit, Abhay (Elsevier, 2010-06)Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. ... -
The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents
Tsiapalis, Dimitrios; De Pieri, Andrea; Spanoudes, Kyriakos; Sallent, Ignacio; Kearns, Stephen; Kelly, Jack L.; Raghunath, Michael; Zeugolis, Dimitrios I. (IOP Publishing, 2020-02-26)Cellular therapies play an important role in tendon tissue engineering, with tenocytes being the most prominent and potent cell population available. However, for the development of a rich extracellular matrix tenocyte-assembled ...