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dc.contributor.authorMurray, Cliodhna E.
dc.contributor.authorColeman, Cynthia M.
dc.identifier.citationMurray, Cliodhna E., & Coleman, Cynthia M. (2019). Impact of Diabetes Mellitus on Bone Health. International Journal of Molecular Sciences, 20(19), 4873, DOI: 10.3390/ijms20194873en_IE
dc.description.abstractLong-term exposure to a diabetic environment leads to changes in bone metabolism and impaired bone micro-architecture through a variety of mechanisms on molecular and structural levels. These changes predispose the bone to an increased fracture risk and impaired osseus healing. In a clinical practice, adequate control of diabetes mellitus is essential for preventing detrimental effects on bone health. Alternative fracture risk assessment tools may be needed to accurately determine fracture risk in patients living with diabetes mellitus. Currently, there is no conclusive model explaining the mechanism of action of diabetes mellitus on bone health, particularly in view of progenitor cells. In this review, the best available literature on the impact of diabetes mellitus on bone health in vitro and in vivo is summarised with an emphasis on future translational research opportunities in this field.en_IE
dc.description.sponsorshipThe Health Research Board and Diabetes Ireland Research Alliance under the MRCG-HRB Joint Funding Scheme (HRB-MRCG-2016-2) funded this research.en_IE
dc.relation.ispartofInternational Journal Of Molecular Sciencesen
dc.subjectdiabetes mellitusen_IE
dc.subjecttype 1 complicationsen_IE
dc.subjecttype 2 complicationsen_IE
dc.subjectbone remodelingen_IE
dc.subjectfracture healingen_IE
dc.subjectbone marrow dysfunctionen_IE
dc.subjectmesenchymal stem cellsen_IE
dc.titleImpact of diabetes mellitus on bone healthen_IE
dc.contributor.funderHealth Research Boarden_IE
dc.contributor.funderDiabetes Ireland Research Allianceen_IE
dc.local.contactCynthia Coleman, School Of Medicine, Nui Galway. 5852 Email:

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