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Now showing items 211-214 of 214
Dynamics of GFP tagged chromatin factors RSF1, CENPS and CENPX at microirradiation induced DNA damage sites
(NUI Galway, 2022-02-22)
Chromatin has a major influence on the DNA damage response (DDR). Several chromatin-related factors contribute to the DDR including the CENPS and CENPX histone fold proteins, also known as MHF1 and MHF2, and the chromatin ...
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
(NUI Galway, 2020-02-04)
Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ...
Enhancing the immunomodulatory efficacy of allogeneic mesenchymal stromal cells through pro-inflammatory cytokine licensing
(NUI Galway, 2024-04-17)
The therapeutic efficacy and immunomodulatory potential of mesenchymal stromal cells (MSCs) is well established. MSCs have been employed as cellular therapies to treat various inflammatory-based conditions. MSC potency can ...
Factors influencing heterogeneity in anthropometric and metabolic responses to structured lifestyle interventions
(NUI Galway, 2024-04-16)
The rising prevalence of obesity is a significant burden on affected individuals, on healthcare systems
and on society. Diet and physical activity are critical determinants of body weight and obesity risk,
and lifestyle ...