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Processing the scientific literature for protein relations (for myocardial infarction) and validation of hypothetical relations through experimental results
(NUI Galway, 2020-02-28)
The last decade has been characterized by a deluge of published scientific literature as well as data generation by biological experiments. The major impediment for the research community to unlock the knowledge contained ...
The role of the aquatic environment in the spread of antimicrobial resistance of public health significance
(NUI Galway, 2020-02-27)
Antimicrobial resistance (AMR) is one of the greatest threats to human health of the 21st Century, with certain antimicrobial resistant organisms classified as being a greater threat to public health than others. At the ...
An investigation of the role of the hypersialylated myeloma cell surface in facilitating evasion of natural killer cell-mediated immunosurveillance
(NUI Galway, 2021-12-30)
Abnormal glycosylation is a hallmark of cancer, and hypersialylation in particular has been shown to facilitate abnormal cell trafficking and drug resistance in many cancers, including Multiple Myeloma (MM) - a currently ...
Adaptive clinical trials of sodium lowering in chronic kidney disease and dialysis: Analytic and methodologic challenges
(NUI Galway, 2022-04-24)
The incidence and prevalence of kidney failure requiring dialysis is rising. Patients receiving dialysis are at increased cardiovascular risk, compared to the general population. Hypertension due to sodium and volume excess ...
Impact of interventions for obesity on insulin sensitivity using the leptin to adiponectin ratio
(NUI Galway, 2021-11-13)
Introduction:
Low energy meal replacement regimens can induce short-term weight loss in patients with severe obesity, but usually require specially formulated dietary supplements. Hypocaloric diets are known to induce ...
The role of glycosylation in intervertebral disc degeneration: Towards glyco-functionalised therapeutics
(NUI Galway, 2021-09-24)
Low back pain (LBP) is a common health issue that imposes a significant socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the major contributing causes of LBP. It is initiated by altered ...
Importance of the caregiver in lifestyle interventions for cognitive impairment
(NUI Galway, 2022-04-11)
Lifestyle risk factors have been identified as key targets for dementia prevention strategies, with most clinical trials targeting individual-level interventions. However, many lifestyle behaviours are known to cluster ...
Subtotal ablation and hyperthermia in the adrenal cortex
(NUI Galway, 2021-08)
Primary aldosteronism (PA) accounts for 5–12% of all hypertension and confers a higher risk for cardiovascular and cerebrovascular complications compared to age and blood pressure (BP) matched essential hypertension. PA ...
A qualitative exploration of the factors that influence healthcare decision-making in the management of end stage renal disease in older adults in Ireland.
(NUI Galway, 2021-12-10)
Background
Older patients with end-stage renal disease (ESRD) are willing participants in advance care planning
(ACP) but just over 10% engage in it (1-3), potentially as nephrologists fear such conversations may
upset ...
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
(NUI Galway, 2022-06-28)
Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ...