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The role of the endocannabinoid system in neuronal alterations and behavioural responding in the valproic acid model of autism
(NUI Galway, 2020-10-20)
Autism is a neurodevelopmental disorder which affects 1 in 54 children. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of autism. Similarly, prenatal exposure of rodents ...
Ablation of FAP+ stromal cells impairs endogenous revascularization during hind limb ischemia
(NUI Galway, 2020-05-08)
Stromal cells have long been studied for their putative role in maintaining tissue homeostasis,
driving tissue remodeling processes during injury, and modulating inflammation by
synergizing with immune cells. Studying ...
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)
Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the
tumour and bypass the host immune system. Extracellular Vesicles (EVs) are
thought to be a fingerprint of the parent cell and therefore MSC-EVs ...
Feasibility of mesenchmyal stem cells as modulators of inflammation and as a cellular model to study cartilage damage in osteoarthritis
(NUI Galway, 2020-04-10)
Osteoarthritis (OA) is the most common degenerative condition affecting whole joints and causing pain and cartilage degeneration, particularly in the elderly population. Inflammation of the synovium is now recognised as ...
Changes in anthropometric and metabolic outcomes during and after a milk-based meal replacement programme in bariatric patients
(NUI Galway, 2020-04-14)
During this work, I examined a cohort of patients with severe and complicated obesity undergoing a milk-based intensive weight management programme, examining changes in various traits in the short and medium term.
Firstly, ...
Optimising endovenous strategies in the management of symptomatic venous incompetence
(NUI Galway, 2021-05-01)
Venous incompetence represents a significant burden of disease globally. In
recent decades the emergence of endovenous ablative techniques have led to a
paradigm shift in the management of venous incompetence. These ...
Cervical lymphadenopathy in lung cancer
(NUI Galway, 2021-09-18)
Overall, in the thesis we showed that cervical lymphadenopathy is frequently present in patients with lung cancer and mediastinal lymphadenopathy on CT to a degree that justifies screening for it routinely. We have shown ...
Blood biomarker monitoring in professional soccer: Longitudinal analysis of inflammation in English Premier League players
(NUI Galway, 2021-09-06)
The high intensity demands of elite soccer predispose players to recurrent episodes of acute inflammation, and during periods of frequent match play recovery time may not be adequate for the resolution of the inflammatory ...
A core outcome set for the treatment of pregnant women with pregestational diabetes: An international consensus study
(NUI Galway, 2021-09-10)
Background
Meaningful comparisons between studies evaluating interventions of pregnant women with pre-gestational diabetes mellitus (PGDM) are limited due to the heterogeneity in outcome selection and reporting. The aim ...
Towards an additive manufactured macroencapsulation device for islet cell replacement therapy
(NUI Galway, 2020-07-28)
Islet encapsulation devices can induce a Foreign Body Response (FBR) and the formation of a hardened avascular fibrotic capsule. This FBR is heightened when the device features a smooth surface as fibrous tissue is unable ...