NUI Galway Theses (PhD Theses)
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Urothelial carcinoma: Molecular profiling and potential application in clinical practice
(NUI Galway, 2020-02-19)Urothelial Carcinoma: Molecular Profiling & Potential Application in Clinical Practice Abstract Introduction: Urothelial carcinoma is characterised by a tendency to recurrence and risk of progression that necessitates ... -
Implications of histone H2AX abundance in breast cancer
(NUI Galway, 2019-12-09)Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ... -
Graph-based diffusion methods for node classification and link prediction
(NUI Galway, 2020-02-13)Graphs are common representation tools to organize information from heterogeneous sources. They have been applied in various domains such as the scientific, engineering, political, and business sectors. The large volume ... -
The evolution of behaviours in swarms of robots
(NUI Galway, 2019-12-09)Evolutionary swarm robotics uses evolutionary computational techniques to synthesise behaviours for a group of autonomous robots. In a swarm of robots, the collective behaviour of the robots results from the local interactions ... -
Sheltered work and intellectual disability equality: Can the UN Convention on the Rights of Persons with Disabilities tackle this form of segregation?
(NUI Galway, 2020-02-13)This thesis is a theoretical study that addresses the enduring segregation of people with intellectual disabilities in sheltered work environments. Having identified that many people with intellectual disabilities remain ... -
'The Problem of the Mentally Handicapped': statutory policy, voluntary provision and intellectual disability in Ireland, 1947-84
(NUI Galway, 2020-02-12)This thesis is a historical investigation of how the state and voluntary sector responded to intellectual disability in Ireland, from the foundation of the Department of Health in 1947 to the 1984 Towards a Full Life Green ... -
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s chemical structure and the type of immune response triggered. This thesis work has focused on the design, synthesis and ... -
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Towards improved performance of mediated glucose oxidising enzyme electrodes for biosensing and biopower applications
(NUI Galway, 2019-11)Energy produced through enzymatic catalysis at electrodes, namely oxidation of glucose and reduction of oxygen may be used to power devices. The goal of powering implantable or semiimplantable medical devices through ... -
Control of polymorphism, crystal size and habit in pharmaceuticals
(NUI Galway, 2019-09)Crystallization is widely used as a purification method of Active Pharmaceutical Ingredients, APIs. During the process a crystalline compound is generally obtained, and it can display general properties and characteristics ... -
A role for USP9X in homologous recombination repair of DNA double strand breaks
(NUI Galway, 2020-02-11)In order to prevent the deleterious effects of a variety of genotoxic agents, cells have developed complex surveillance mechanisms and multiple DNA repair pathways that allow them to maintain genome integrity. The ... -
Microplastic pathways in marine pelagic systems
(NUI Galway, 2020-02-07)Marine litter and microplastics in particular have for some time now been postulated to be of environmental concern. Despite the ever-increasing amount of microplastic studies, conclusive evidence of the adverse effects ... -
Experimental and finite element investigations of the serviceability behaviour of CLT floors
(NUI Galway, 2020-02-06)Global environmental concerns with regard to sustaining our growing population is prompting the building community worldwide to increase urban density, while using optimised and sustainable resources. The traditional ... -
Analysis of the behaviour of hybrid concrete lattice girder slabs during construction using laboratory and field testing
(NUI Galway, 2020-01-31)One of the emerging technologies in construction is the development of ‘smart structures’ which have sensors which will allow more efficient, resilient and sustainable structures to be designed and constructed. This research ... -
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
(NUI Galway, 2020-02-04)Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ... -
Identification of plant-specific components of the Polycomb Group pathway and their roles in the regulation of Arabidopsis thaliana development
(NUI Galway, 2019-09-30)The knowledge about Arabidopsis thaliana developmental life cycle is deep in broad strokes. Nevertheless, the mechanisms that fine tune these phase transitions are still poorly described. One of these mechanisms is the ... -
Sustainable treatment technologies using mixed waste media to mitigate agricultural contaminants in land drainage
(NUI Galway, 2020-01-30)Intensification of agriculture in the European Union has resulted in nutrient losses from farms, which have contributed to a deterioration in water quality. As soil in drainage water ditch networks has limited capacity to ... -
Anti-inflammatory hydrogel enrichment for cell-based brain repair in Parkinson's disease
(NUI Galway, 2020-01-28)Cell transplantation as a therapeutic approach for Parkinson’s disease has been extensively studied over the past decades. The transplantation of primary dopaminergic neurons in the degenerated striatum has shown that these ... -
Investigation of radon prevention and mitigation: from radon measurements to specification for soil depressurisation systems
(NUI Galway, 2020-01-27)Reduction of indoor radon concentration in buildings is considered to be an important public health issue, since radon was recognised as the leading cause of lung cancer after tobacco smoking by the World Health Organisation. ... -
Noise in nonsmooth dynamical systems
(NUI Galway, 2020-01-24)This article-based thesis comprises a collection of four articles, each of which constitutes a chapter, written and formatted in pre-print manuscript form. The general aim underlying these articles is to understand how ...