NUI Galway Theses (PhD Theses)
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A refined model of nucleolar formation derived from the analysis of UBF variants and the hierarchical silencing of human nucleolar organizer regions
(NUI Galway, 2017-03-23)The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed nucleolar organizer regions (NORs). As the site of ribosome biogenesis, nucleolar function is intrinsically linked to ... -
Taxonomy, parataxonomy, and metabarcoding: an investigation of invertebrate diversity in high nature value wet grasslands
(NUI Galway, 2017-11-01)Wet grassland habitats characterised by seasonal inundation and low-intensity agricultural practices support a rich mosaic of plant and animal communities. Whilst most of the conservation strategies aimed at protecting ... -
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
(NUI Galway, 2018-04-13)There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ... -
Planet engulfment and the planetary nebula morphology mystery
(NUI Galway, 2018-04-13)This thesis presents an investigation into the galactic population of planetary nebulae (PNe) whose progenitors have evolved through the engulfment of massive planets during the asymptotic giant branch (AGB) phase of their ... -
Openness and praxis: A situated study of academic staff meaning-making and decision-making with respect to openness and use of open educational practices in higher education
(NUI Galway, 2018-04-12)Open education seeks to improve educational access, effectiveness, and equality. The term ‘open educational practices’ (OEP) describes practices that include the creation, use and reuse of open educational resources (OER) ... -
Investigations into soil microbiome stability in the face of agriculture and climate change related perturbations
(NUI Galway, 2017-11-05)Soils and the vital ecosystem services performed by their indigenous microbiota are under increasing pressure from anthropogenic stresses and climate change. In an effort to understand how the provision of soil ecosystem ... -
Evaluation of the efficacy of the Baska Mask
(NUI Galway, 2018-03-22)The Baska mask is a new supraglottic airway device (SAD). Its novel features include a non-inflatable cuff consisting of a silicone membrane, and an oesophageal drainage system with sump reservoir, connected to 2 drainage ... -
Equally existing objects: Tracing the emergence of non-hierarchical being through film and Occupy Wall Street
(NUI Galway, 2017-04-06)This project aims to trace the emergence of a non-hierarchical being, from 1999 to roughly 2013. The type of being under discussion is one that allows for all things to equally exist, outside of a human-world correlation, ... -
"We here in Ireland are not outside this struggle": the Irish Catholic Church, anti-communism and the Cold War, 1945-1965
(NUI Galway, 2018-04-03)This project explores an understudied aspect of modern Irish Catholicism by examining the anticommunism of the Irish Catholic Church in the period from 1945 to 1965, which marked the early years of the Cold War. It looks ... -
Observational based evaluation of air-sea gas fluxes and turbulence in the surface ocean boundary layer
(NUI Galway, 2018-04-09)Turbulence within the ocean surface boundary layer (OSBL) is an important quantity for many processes as it mixes the ocean and transports various ocean quantities such as pollutants, heat, and dissolved gases. ... -
A role for nanor in early zebrafish development and validation of a neurotoxic zebrafish model of Parkinson’s disease
(NUI Galway, 2018-04-06)Zebrafish are a versatile experimental model which have progressed the fields of many research areas through both genetic and pharmacological studies. In this thesis I studied a novel zygotic gene, nanor, in zebrafish and ... -
Hybrid systems modelling aided by machine learning with applications in healthcare
(NUI Galway, 2018-03)Recent trends towards data-driven methods may require a substantial rethinking of the process of developing simulation models. For instance, Machine Learning (ML) has demonstrated great potentials for constructing new ... -
Novel functions for the CENP-A N-terminus during male meiosis in Drosophila melanogaster
(NUI Galway, 2018-03-23)Recent studies in plants and Drosophila suggest that CENP-A, the centromeric histone H3 variant and epigenetic marker of centromere localisation may have additional roles during meiosis. By immunoprecipitation and mass ... -
Bayesian imputation of right censored data in time-to-event studies
(NUI Galway, 2018-03-20)In time-to-event studies subjects are followed until the event of interest has happened. Subjects who do not experience the event are referred to as censored. Due to censoring, methods of plotting individual survival ... -
Understanding the economics of land access in Ireland
(NUI Galway, 2018-03-28)This thesis analyses land availability and mobility in Ireland. The thesis begins with an overview of the economic theory of agricultural land markets followed by a description of Ireland’s current land use structures and ... -
Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
(NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Translational statistics and dynamic nomograms
(NUI Galway, 2018-03-21)Translational Medicine, within biomedical and public health research domains, is defined as the convergence of basic and clinical research with the aim to transfer knowledge on the benefits and risks of therapies. The ... -
Social and clinical features of HIV infection in older children and adolescents in Zimbabwe
(2017-09-29)Introduction HIV infection has had a devastating effect on morbidity and mortality of children and adolescents, particularly in low- income settings. Zimbabwe has been at the epicentre of the HIV epidemic since mid-1990. ... -
Wolveridge's Speculum Matricis: a mirror on antiquity?
(2018-03-07)The main aim of this study of Wolveridge’s Speculum Matricis of 1670 is to ascertain the extent to which his midwifery manual fitted within the still dominant Greek medical model, and how, if at all, it reflected influences ... -
The influence of collagen isolation, cross-linking and sterilisation on macrophage response
(2018-03-07)Collagen-based devices are frequently associated with foreign body response. Although several pre- (e.g. species, state of animal, tissue, isolation protocol) and post- (e.g. cross-linking, scaffold architecture, sterilisation) ...