NUI Galway Theses (PhD Theses)
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A study in carbohydrate chemistry: From anomerisation to synthesis of glycoclusters based on neoglycopeptides
(NUI Galway, 2018-08-08)1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ... -
Capability architecture for open data
(NUI Galway, 2018-07-31)Open data is increasingly becoming an essential asset for many organizations. Large numbers of new start-ups are emerging to benefit from the potential of this asset for a wide range of new products and services. However, ... -
Developing the evidence base for a digital intervention to enhance adherence to medication in people with hypertension
(NUI Galway, 2018-07-17)Background. Hypertension is a chronic condition in which the blood vessels have persistently raised pressure. It is a major modifiable risk factor for both cardiovascular and cerebrovascular disease. Hypertension is estimated ... -
Waves, wrinkles and creases in deformed soft solids
(NUI Galway, 2018-07-10)This article-based thesis comprises a collection of four articles, each of which constitutes a chapter written and formatted in pre-print manuscript form. The general aim underlying these articles is to model the large ... -
The role of facilitation and social processes in collaborative learning: Implications for the design of an applied systems science curriculum
(NUI Galway, 2018-07-24)Resolving complex scientific and social problems requires effective collaboration. In the absence of adequate facilitation and the use of a structured methodology, however, collaborative groups often fail to reach their ... -
Building envelope thermal bridging heat loss assessment using infrared thermography
(NUI Galway, 2018-07-25)Reduction of greenhouse gas emissions and energy use is necessary to stop the progress of climate warming, which may have a serious impact on the human environment and the ecosystem. To achieve this reduction, it is essential ... -
Upper ocean responses to solar heating and rain
(NUI Galway, 2018-07-20)This thesis presents observations made in the ocean surface boundary layer (OSBL), with the Air-Sea Interaction Profiler (ASIP), in conjunction with measurements of meteorological variables. These are used to establish ... -
Development and evaluation of an assessment tool for identification of elements of situation awareness in OSCEs in undergraduate medical curricula
(NUI Galway, 2018-07-20)Situation awareness (SA) is recognised as an important factor in patient safety and clinical decision making in conjunction with diagnostic and therapeutic reasoning. Missed diagnosis and treatment errors have been identified ... -
Therapeutic targets for duchenne muscular dystrophy
(NUI Galway, 2018-07-05)Duchenne Muscular Dystrophy (DMD) is a progressive X-linked fatal muscle degenerative disorder caused by the absence of the sarcolemmal associated dystrophin-glycoprotein complex (DGC) that connects the intracellular ... -
Biodiversity and performance of constructed wetlands; a comparison with natural wetlands
(NUI Galway, 2018-07-03)Natural wetlands (NWs) are one of the most economically and ecologically important habitats on Earth, currently comprising about 6% of the world’s surface area. They provide many ecosystem services including the supply of ... -
Cell cycle regulation of centromere assembly in Drosophila male meiosis
(NUI Galway, 2018-03-16)Centromeres are chromosomal sites required for faithful chromosome segregation. CENP-A is the histone H3 variant that demarcates centromeres from bulk chromatin. Errors in centromere assembly result in segregation defects ... -
Integrated assessment of sheep production systems and the agricultural value chain
(NUI Galway, 2018-07-02)This thesis describes the development of an integrated, farm level, bioeconomic systems model of Irish sheep production using nationally representative data from the National Farm Survey (NFS). A systems approach is applied ... -
Studies in anomerisation of glycosyl thiols and glycosides
(NUI Galway, 2018-06-29)The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers a facile method to generate 1,2-cis ... -
On the application of analytical techniques to mobile network CDRs for the characterisation and modelling of subscriber behaviour
(NUI Galway, 2018-06-13)This thesis describes work completed on the characterisation and modelling of the behaviour of subscribers in mobile phone networks implementing dynamic pricing by means of Call Detail Records (CDR) datasets analysis. The ... -
Characterisation of triple negative breast carcinoma and identification of the value of immunohistochemical markers and stromal tumour infiltrating lymphocytes
(NUI Galway, 2017-10)Breast cancer is a complex disease that encompasses multiple molecular subtypes that have different clinical behavior. The behavior can be influenced by both the characteristics of the cancer cells as well as the surrounding ... -
Contributions to the measurement of depth in consumer imaging
(NUI Galway, 2018-06-12)This thesis aims to examine and investigate methods that could potentially utilize images captured by consumer cameras such as smartphones to estimate depth and generate a 3D structure. After more than a century of ... -
ATR mediated regulation of the abscission checkpoint
(NUI Galway, 2018-05-30)Unperturbed mitotic cell division is essential for survival. For cells to complete mitosis, genetic material must be distributed equally between the new cells before the final abscission. Failure to complete chromosome ... -
From Gaelic lordships to English counties: the Tudor transition in Leix and Offaly, c.1547-1603
(NUI Galway, 2018-05-29)This study evaluates whether or not successive Tudor regimes effectively transformed the Gaelic lordships of Leix and Offaly into English counties and as a direct consequence, administered these territories through the ... -
Pro-inflammatory cytokine licensing as a strategy to enhance the efficacy of syngeneic mesenchymal stem cells for corneal transplantation
(NUI Galway, 2018-05-11)It has previously been demonstrated by our lab that allogeneic MSCs prolong corneal allograft survival however syngeneic MSCs fail to do so. The aim of this study was to investigate if pre-treating syngeneic MSCs with ... -
Aspects of modeling and application of survival-type data
(NUI Galway, 2018-02)Survival analysis is collection of methods for analyzing data where the outcome of interest is the time to an event and some of the observations are censored. Survival data can arise naturally from studies on, machines' ...