Search
Now showing items 11-19 of 19
A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response
(NUI Galway, 2019-04-23)
Reproducing the systems biology efforts established across areas of cell biology such as integrating biological networks with omic datasets and subjecting it to modelling analysis for studying the functional involvement ...
Investigations of spicules and spicule formation in Haplosclerida (Porifera, Demospongiae) using a multidisciplinary approach
(NUI Galway, 2019-01-09)
Sponges are simple animals and their body is formed by different cell types and a dense skeleton either of collagen, chitin or spicules made of amorphous silica or calcium carbonate that they secrete. The phylum Porifera ...
Provenance of Triassic sandstones in NW European Margin Basins - reconstructing palaeogeography using a multi-proxy approach
(NUI Galway, 2019-11-04)
Provenance studies endeavour to unravel the history of a sediment, from investigating potential source rocks, to assessing the processes which may have affected sediment during weathering, transport, burial and diagenesis, ...
Impact of light intensities and low temperature on the composition and diurnal use of transient carbon stores in barley (Hordeum vulgare)
(NUI Galway, 2019-10-18)
The carbon partitioning and accumulation are critical for biomass formation in
plants and can be affected by environmental changes and regulated by circadian clock.
Thus, in this study, barley was grown under three light ...
Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks
(NUI Galway, 2019-12-16)
The integrity of our genome is very important therefore, our cells have developed efficient DNA
repair mechanisms to control this integrity and avoid mutations. Although the DNA double
strand break response pathway is ...
Investigation of biological factors that may contribute to bioactivity in Haliclona (Porifera, Haplosclerida)
(NUI Galway, 2019-09-06)
Sponges (phylum Porifera) are considered the most prolific source of
bioactive compounds of marine origin. These molecules have varied
chemical nature and have been shown to possess several properties, e.g.
antibacterial, ...
Characterisation of human nucleolar organisers located in previously uncharted regions of the human genome
(NUI Galway, 2019-01-18)
The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis.
Nucleoli form around chromosomal loci called ‘nucleolar organiser regions (NORs)
located on the short arms of the human acrocentric ...
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)
The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ...
Identifying novel drug therapies for acute myeloid leukaemia by targeting the interactions between leukaemia cells and bone marrow microenvironment
(NUI Galway, 2019-10-25)
Acute myeloid leukaemia (AML) is a malignancy caused by a block in differentiation in which
aberrant leukemic stem cells drive the production of undifferentiated or partially differentiated
leukemic blast cell clones. ...