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Characterisation of histone variants in the cnidarian Hydractinia
(NUI Galway, 2019-02-21)
Hydractinia is a marine hydrozoan cnidarian that has been a model organism for developmental biology for over a century. Very few studies have been carried out on chromatin biology in cnidarians. To date, there is no ...
Investigation of the genetic basis of schizophrenia and cognitive function
(NUI Galway, 2019-01-25)
Schizophrenia (SZ) is a chronic psychiatric disorder affecting approximately 1% of the population. Symptoms range from delusional thoughts and hallucinations to anhedonia and social withdrawal. Affected individuals also ...
Effects of exogenous B-cell immunoglobulin binding protein (BIP) and BIP protein inducer X (BIX) on myelination
(NUI Galway, 2019-12-12)
B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone that belongs to the Hsp70 family, normally found in the ER lumen. However, BiP also has other extracellular and intracellular ...
Reverse genetic analysis of centrosomal roles of Checkpoint Kinase 1
(NUI Galway, 2019-06-14)
Centrosome duplication is tightly regulated process that occurs only once per cell cycle. Centrosome abnormalities have been observed in cancer cells and in cells with defective DNA damage responses. Genotoxic stresses ...
Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks
(NUI Galway, 2019-12-16)
The integrity of our genome is very important therefore, our cells have developed efficient DNA
repair mechanisms to control this integrity and avoid mutations. Although the DNA double
strand break response pathway is ...
Characterisation of human nucleolar organisers located in previously uncharted regions of the human genome
(NUI Galway, 2019-01-18)
The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis.
Nucleoli form around chromosomal loci called ‘nucleolar organiser regions (NORs)
located on the short arms of the human acrocentric ...
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)
The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ...
Identifying novel drug therapies for acute myeloid leukaemia by targeting the interactions between leukaemia cells and bone marrow microenvironment
(NUI Galway, 2019-10-25)
Acute myeloid leukaemia (AML) is a malignancy caused by a block in differentiation in which
aberrant leukemic stem cells drive the production of undifferentiated or partially differentiated
leukemic blast cell clones. ...