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A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights
(Royal Society of Chemistry, 20161201)A new Cubased anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction ... 
A comprehensive cocrystal screening study of chlorothiazide
(American Chemical Society, 20170901)Cocrystal formation of chlorothiazide (ctz) was screened with a variety of coformers with carboxyl, amide, hydroxyl, sulfonamide, pyridine, amidine, and amine functional groups. New cocrystals with acetamide (aca), benzamide ... 
Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4phenylbutyric acid
(Elsevier, 20170910)Five new platinum(IV) derivatives of carboplatin each incorporating the histone deacetylase inhibitor 4phenylbutyrate in axial position were synthesized and characterized by 1H and 195Pt NMR spectroscopy, electrospray ... 
A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations
(Elsevier, 20170608)Understanding phase transitions in pharmaceutical materials is of vital importance for drug manufacturing, processing and storage. In this paper we have carried out comprehensive highresolution spectroscopic studies on ... 
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drugNaTc systems
(Elsevier, 20181028)The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the Xray powder pattern showed an amorphous halo after milling at room temperature or ... 
Applications of raman spectroscopy in biopharmaceutical manufacturing: A short review
(Sage Publications, 20170523)The production of active pharmaceutical ingredients (APIs) is currently undergoing its biggest transformation in a century. The changes are based on the rapid and dramatic introduction of protein and macromoleculebased ... 
Investigation of depthresolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation
(2013)We present depthresolved spatialdomain lowcoherence quantitative phase microscopy, a simple approach that utilizes coherence gating to construct a depthresolved structural feature vector quantifying subresolution axial ... 
Synthesis of migrastatin analogues as inhibitors of tumour cell migration: Exploring structural change in and on the macrocyclic ring
(Wiley, 20151104)Migrastatin and isomigrastatin analogues have been synthesised in order to contribute to structureactivity studies on tumour cell migration inhibitors. These include macrocycles varying in ring size, functionality and ... 
Surface stability of nonlinear magnetoelastic solids
(Wiley, 200712)The present paper proposes to identify surface stability when a magnetoelastic halfspace is subjected to a pure homogeneous predeformation and to a magnetic field normal to its (plane) boundary. Clearly, the aim is to ... 
Solvothermal synthesis of discrete cages and extended networks comprising {Cr(III)3O(O2CR)3(oxime)3}2 (R = H, CH3, C(CH3)3, C14H9) building blocks
(Royal Society of Chemistry, 20160728)The synthesis, structural and magnetic characterisation of a family of related Cr(III) cages are reported. Each member comprises {Cr(III)3O(O2CR1)3(R2sao)3}2 (R1 = H, CH3, C(CH3)3, C14H9 ; R2 = Me, Ph, tBu, C10H8) triangles ... 
Does the chemical diversity of the Order Haplosclerida (Phylum Porifera: Class Demospongia) fit with current taxonomic classification?
(Georg Thieme Verlag, 20160502)Sponges and their associated microbiota are well known to produce a large diversity of natural products, also called specialized metabolites. In addition to their potential use in the pharmaceutical industry, these rather ... 
Sophisticated clean air strategies required to mitigate against particulate organic pollution
(Nature Publishing Group, 20170317)Since the 1980's, measures mitigating the impact of transboundary air pollution have been implemented successfully as evidenced in the 19802014 record of atmospheric sulphur pollution over the NEAtlantic, a key region ... 
Topdown and bottomup aerosolcloud closure: towards understanding sources of uncertainty in deriving cloud shortwave radiative flux
(European Geosciences Union (EGU), 20170822)Topdown and bottomup aerosolcloud shortwave radiative flux closures were conducted at the Mace Head Atmospheric Research Station in Galway, Ireland, in August 2015. This study is part of the BACCHUS (Impact of Biogenic ... 
Methyl 2,3,6triOBenzoyl4O(tertbutyldimethylsilyl)βdgalactopyranoside
(MDPI (Multidisciplinary Digital Publishing Institute), 20170319)Methyl 2,3,6triObenzoyl4O(tertbutyldimethylsilyl)βdgalactopyranoside was synthesized in 47% yield by the silylation of a partially benzoylated galactose derivative, prepared from methyl βdgalactopyranoside. ... 
Allylic azide rearrangement in tandem with intramolecular Huisgen cycloaddition for iminosugar and glycomimetic synthesis. Functionalized piperidine, pyrrolidine and pyrrolotriazoles from Dmannose
(Thieme Publishing, 20170420)Intramolecular Huisgen azidealkene cycloaddition reaction of 7azidohepta1,5diene3,4diols, prepared from methyl αdmannopyranoside, were carried out. Allylic azide rearrangement to secondary azides occurred ... 
Stereoselective epimerizations of glycosyl thiols
(American Chemical Society, 20171017)Glycosyl thiols are widely used in stereoselective Sglycoside synthesis. Their epimerization from 1,2trans to 1,2cis thiols (e.g., equatorial to axial epimerization in thioglucopyranose) was attained using TiCl4, while ... 
On the quiver presentation of the descent algebra of the symmetric group
(Elsevier, 20130318)We describe a presentation of the descent algebra of the symmetric group G(n) as a quiver with relations. This presentation arises from a new construction of the descent algebra as a homomorphic image of an algebra of ... 
An inductive approach to Coxeter arrangements and Solomon's descent algebra
(Springer Verlag, 20120720)In our recent paper (Douglass et al. arXiv: 1101.2075 (2011)), we claimed that both the group algebra of a finite Coxeter group W as well as the OrlikSolomon algebra of W can be decomposed into a sum of induced onedimensional ... 
Computing the table of marks of a cyclic extension
(American Mathematical Society, 20120224)The subgroup pattern of a finite group C is the table of marks of G together with a list of representatives of the conjugacy classes of subgroups of G. In this article we present an algorithm for the computation of the ... 
Computations for Coxeter arrangements and Solomon's descent algebra: Groups of rank three and four
(Elsevier, 20120603)In recent papers we have refined a conjecture of Lehrer and Solomon expressing the characters of a finite Coxeter group W afforded by the homogeneous components of its OrlikSolomon algebra as sums of characters induced ...