College of Science
Browse by
Sub-communities within this community
Recent Submissions
-
Supramolecular stacking in a high Z′ calix[8]arene–porphyrin assembly
(Royal Society of Chemistry, 2019-11-15)A co-crystal structure of sulfonato-calix[8]arene (sclx8) and trimethylanilinium-porphyrin (tmap) at 1.0 Å resolution is reported. The oppositely charged macrocycles formed an alternating stacked assembly. Crystal packing ... -
Global and local tests to assess stationarity of Markov transition models
(Taylor & Francis, 2018-02-09)We present global and local likelihood-based tests to evaluate stationarity in transition models. Three motivational studies are considered. A simulation study was carried out to assess the performance of the proposed ... -
A Weibull-count approach for handling under- and overdispersed longitudinal/clustered data structures
(SAGE Publications, 2018-07-30)A Weibull-model-based approach is examined to handle under- and overdispersed discrete data in a hierarchical framework. This methodology was first introduced by Nakagawa and Osaki (1975, IEEE Transactions on Reliability, ... -
Tuning protein frameworks via auxiliary supramolecular interactions
(American Chemical Society, 2019-09-06)Protein crystals with their precise, periodic array of functional building blocks have potential applications in biomaterials, sensing, and catalysis. This paper describes how a highly porous crystalline framework of a ... -
Models for overdispersed data in entomology
(Springer, Cham, 2014-09-17)Entomological data are often overdispersed, characterised by a larger variance than assumed by simple standard models. It is important to model overdispersion properly in order to avoid incorrect and misleading inferences. ... -
Calixarene-mediated assembly of a small antifungal protein
(International Union of Crystallography, 2019-02-05)Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by providing a surface on which two or more ... -
RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster
(eLife Sciences Publications, 2019-11-05)Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that ... -
Investigating native state fluorescence emission of Immunoglobulin G using polarized Excitation Emission Matrix (pEEM) spectroscopy and PARAFAC
(Elsevier, 2018-12-20)Intrinsic fluorescence spectroscopy (IFS) measurements for protein structural analysis can be enhanced by the use of anisotropy resolved multidimensional emission spectroscopy (ARMES). ARMES attempts to overcome the ... -
Multi-attribute quality screening of immunoglobulin G using polarized Excitation Emission Matrix spectroscopy
(Elsevier, 2019-12-10)Immunoglobulin G (IgG) is often used as a starting material for the production of functionalised antibodies, like Antibody Drug Conjugates (ADCs), PEGlyated-conjugates, or radioimmunoconjugates. The gross structural quality ... -
Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure
(Elsevier, 2019-12-20)Concentrations of 10 perfluoroalkyl substances (PFASs) were measured in 16 pools of human milk from Ireland. Only four PFASs were detected (PFOA, PFNA, PFHxS and PFOS), with concentrations dominated by PFOA which was ... -
VERITAS detection of LS 5039 and HESS J1825-137
(Elsevier, 2019-11-07)With 8 h of observations, VERITAS confirms the detection of two very high energy gamma-ray sources. The gamma-ray binary LS 5039 is detected with a statistical significance of 8.8σ. The measured flux above 1 TeV is near ... -
Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale
(Public Library of Science, 2019-09-26)The composition of the mammalian gut microbiota can be influenced by a multitude of environmental variables such as diet and infections. Studies investigating the effect of these variables on gut microbiota composition ... -
Opportunistic bacteria dominate the soil microbiome response to phenanthrene in a microcosm-based study
(Frontiers Media, 2018-11-21)Bioremediation offers a sustainable approach for removal of polycyclic aromatic hydrocarbons (PAHs) from the environment; however, information regarding the microbial communities involved remains limited. In this study, ... -
Animal life history is shaped by the pace of life and the distribution of age-specific mortality and reproduction
(Nature Research (part of Springer Nature), 2019-07-08)Animals exhibit an extraordinary diversity of life history strategies. These realized combinations of survival, development and reproduction are predicted to be constrained by physiological limitations and by trade-offs ... -
Determination of the number of RAD51 molecules in different human cell lines
(Taylor & Francis, 2019-11-15)Knowledge about precise numbers of specific molecules is necessary for understanding and verification of biological pathways. The RAD51 protein is central in the repair of DNA double-strand breaks (DSBs) by homologous ... -
ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn2+
(Wiley Open Access, 2019-08-29)B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone normally found in the ER lumen. However, BiP also has other extracellular and intracellular functions. As it is unclear whether ... -
Identification of putative adhesins and carbohydrate ligands of Lactobacillus paracasei using a combinatorial in silico and glycomics microarray profiling approach
(Oxford University Press (OUP), 2019-11-11)Commensal bacteria must colonize host mucosal surfaces to exert health-promoting properties, and bind to gastrointestinal tract (GIT) mucins via their cell surface adhesins. Considerable effort has been directed towards ... -
Rapid screening for specific glycosylation and pathogen interactions on a 78 species avian egg white glycoprotein microarray
(Nature Research, 2017-07-25)There is an urgent need for discovery of novel antimicrobials and carbohydrate-based anti-adhesive strategies are desirable as they may not promote resistance. Discovery of novel anti-adhesive molecules from natural product ... -
Simulation of quantum circuits by low-rank stabilizer decompositions
(Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften, 2019-09-02)Recent work has explored using the stabilizer formalism to classically simulate quantum circuits containing a few non-Clifford gates. The computational cost of such methods is directly related to the notion of s t a ... -
Microbial electrochemical technologies: Electronic circuitry and characterization tools
(Elsevier, 2019-11-16)Microbial electrochemistry merges microbiology, electrochemistry and electronics to provide a set of technologies for environmental engineering applications. Understanding the electronic concepts is crucial for effectively ...