Recent Submissions

  • Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia 

    Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Wellcome Trust Case Control Consortium 2; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Donohoe, Gary; Gill, Michael; Corvin, Aiden; Morris, Derek W. (Wiley, 2019-02-23)
    Genome‐wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of ...
  • A decade to study deep-sea life. 

    Howell, Kerry L.; Hilário, Ana; Allcock, A. Louise; Bailey, David; Baker, Maria; Clark, Malcolm R.; Colaço, Ana; Copley, Jon; Cordes, Erik E.; Danovaro, Roberto; Dissanayake, Awantha; Escobar, Elva; Esquete, Patricia; Gallagher, Austin J.; Gates, Andrew R.; Gaudron, Sylvie M.; German, Christopher R.; Gjerde, Kristina M.; Higgs, Nicholas D.; Le Bris, Nadine; Levin, Lisa A.; Manea, Elisabetta; McClain, Craig; Menot, Lenaick; Mestre, Nelia C.; Metaxas, Anna; Milligan, Rosanna; Muthumbi, Agnes W. N.; Ramalho, Sofia P.; Ramirez-Llodra, Eva; Robson, Laura M.; Rogers, Alex D.; Sellanes, Javier; Sigwart, Julia D.; Sink, Kerry; Snelgrove, Paul V. R.; Stefanoudis, Paris V.; Sumida, Paulo Y; Taylor, Michelle L.; Thurber, Andrew R.; Vieira, Rui; Watanabe, Hiromi K.; Woodall, Lucy C.; Xavier, Joana R.; Narayanaswamy, Bhavani E. (Nature Research, 2020-11-25)
    The United Nations Decade of Ocean Science for Sustainable Development presents an exceptional opportunity to effect positive change in ocean use. We outline what is required of the deep-sea research community to achieve ...
  • The dairy biorefinery: Integrating treatment processes for cheese whey valorisation 

    Asunis, Fabiano; De Gioannis, Giorgia; Dessì, Paolo; Isipato, Marco; Lens, Piet N.L.; Muntoni, Aldo; Polettini, Alessandra; Pomi, Raffaella; Rossi, Andreina; Spiga, Daniela (Elsevier, 2020-08-28)
    With an estimated worldwide production of 190 billion kg per year, and due to its high organic load, cheese whey represents a huge opportunity for bioenergy and biochemicals production. Several physical, chemical and ...
  • Propionate production by bioelectrochemically-assisted lactate fermentation and simultaneous CO2 recycling 

    Isipato, Marco; Dessì, Paolo; Sánchez, Carlos; Mills, Simon; Ijaz, Umer Z.; Asunis, Fabiano; Spiga, Daniela; De Gioannis, Giorgia; Mascia, Michele; Collins, Gavin; Muntoni, Aldo; Lens, Piet N. L. (Frontiers Media, 2020-12-15)
    Production of volatile fatty acids (VFAs), fundamental building blocks for the chemical industry, depends on fossil fuels but organic waste is an emerging alternative substrate. Lactate produced from sugar-containing waste ...
  • Organic waste biorefineries: Looking towards implementation 

    Alibardi, Luca; Astrup, Thomas F.; Asunis, Fabiano; Clarke, William P.; De Gioannis, Giorgia; Dessì, Paolo; Lens, Piet N.L.; Lavagnolo, Maria Cristina; Lombardi, Lidia; Muntoni, Aldo; Pivato, Alberto; Polettini, Alessandra; Pomi, Raffaella; Rossi, Andreina; Spagni, Alessandro; Spiga, Daniela (Elsevier, 2020-07-16)
    The concept of biorefinery expands the possibilities to extract value from organic matter in form of either bespoke crops or organic waste. The viability of biorefinery schemes depends on the recovery of higher-value ...
  • Fermentative hydrogen production from cheese whey with in-line, concentration gradient-driven butyric acid extraction 

    Dessì P, Asunis F, Ravishankar H, Cocco FG, De Gioannis G, Muntoni A, Lens PNL; Dessì, Paolo; Asunis, Fabiano; Ravishankar, Harish; Cocco, Francesco Giuseppe; De Gioannis, Giorgia; Muntoni, Aldo; Lens, Piet N.L. (Elsevier, 2020-08-01)
    Hydrogen (H2) generation from cheese whey with simultaneous production and extraction of volatile fatty acids (VFAs) was studied in UASB reactors at two temperatures (20 and 35 °C) and pH values (5.0 and 4.5). The extraction ...
  • Microbial electrosynthesis: Towards sustainable biorefineries for production of green chemicals from CO2 emissions 

    Dessì, Paolo; Rovira-Alsina, Laura; Sánchez, Carlos; Dinesh, G. Kumaravel; Tong, Wenming; Chatterjee, Pritha; edesco, MicheleT; Farràs, Pau; Hamelers, Hubertus M.V.; Puig, Sebastià (Elsevier, 2020-12-01)
    Decarbonisation of the economy has become a priority at the global level, and the resulting legislative pressure is pushing the chemical and energy industries away from fossil fuels. Microbial electrosynthesis (MES) has ...
  • Carboxylic acids production and electrosynthetic microbial community evolution under different CO2 feeding regimes 

    Dessì, Paolo; Sánchez, Carlos; Mills, Simon; Cocco, Francesco Giuseppe; Isipato, Marco; Ijaz, Umer Z.; Collins, Gavin; Lens, Piet N.L. (Elsevier, 2020-10-15)
    Microbial electrosynthesis (MES) is a potential technology for CO2 recycling, but insufficient information is available on the microbial interactions underpinning electrochemically-assisted reactions. In this study, a MES ...
  • OpenTCC: An open source low-cost temperature-control chamber 

    Sánchez, Carlos; Dessì, Paolo; Duffy, Maeve; Lens, Piet N.L. (Elsevier, 2020-02-24)
    Microbial electrochemical technologies (MET) are emerging systems for environmental applications such as renewable energy production or pollution remediation. MET research often requires stable temperatures and low levels ...
  • The awarding of the first honorary Doctor of Science by the Queen's University in Ireland to William King – a journey of scientific curiosity 

    Murray, John; Dingsdale, Ann; Nasheuer, Heinz-Peter; Harper, David A.T. (Royal Irish Academy, 2020)
    William King (1809 86) was the founding Professor of Mineralogy and Geology at Queen s College Galway (QCG), one of three regional colleges opened in 1849 to provide secular university-level education in Ireland. King came ...
  • Inhibition of human BK polyomavirus replication by small noncoding RNAs 

    Tikhanovich, Irina; Liang, Bo; Seoighe, Cathal; Folk, William R.; Nasheuer, Heinz-Peter (American Society for Microbiology Journals, 2011)
    Small noncoding RNAs regulate a variety of cellular processes, including genomic imprinting, chromatin remodeling, replication, transcription, and translation. Here, we report small replication-regulating RNAs (srRNAs) ...
  • Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy 

    Broderick, Ronan; Ramadurai, Sivaramakrishnan; Tóth, Katalin; Togashi, Denisio M.; Ryder, Alan G.; Langowski, Jörg; Nasheuer, Heinz-Peter (Public Library of Science, 2012-04-19)
    Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ...
  • Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage 

    Broderick, Ronan; Rainey, Michael D.; Santocanale, Corrado; Nasheuer, Heinz-Peter (Wiley, 2013-08-02)
    The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays an important role in the intra-S-phase checkpoint. Its interactions with other replication ...
  • Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences 

    Ali, Rizwan; Ramadurai, Sivaramakrishnan; Barry, Frank; Nasheuer, Heinz-Peter (Wiley, 2018-04-16)
    The modulation of expression levels of fluorescent fusion proteins (FFPs) is central for recombinant DNA technologies in modern biology as overexpression of proteins contributes to artifacts in biological experiments. In ...
  • Alkoxyalkyl esters of nucleotide analogs inhibit polyomavirus DNA replication and large T antigen activities 

    Onwubiko, Nichodemus O.; Diaz, Suraya; Krecmerova, Marcela; Nasheuer, Heinz-Peter (American Society for Microbiology Journals, 2020-12-07)
    Polyomavirus-related infections are ubiqutious in immunocompromised individuals and in some cases are intractable and fatal. Due to lack of approved drugs to treat polyomavirus infections, cidofovir, a phosphonate nucleotide ...
  • SV40 T antigen interactions with ssDNA and replication protein A: a regulatory role of T antigen monomers in lagging strand DNA replication 

    Onwubiko, Nichodemus O.; Borst, Angela; Diaz, Suraya A.; Passkowski, Katharina; Scheffel, Felicia; Tessmer, Ingrid; Nasheuer, Heinz-Peter (Oxford University Press (OUP), 2020-03-04)
    DNA replication is a central process in all living organisms. Polyomavirus DNA replication serves as a model system for eukaryotic DNA replication and has considerably contributed to our understanding of basic replication ...
  • Development of an ethogram for hutch-housed dairy calves and determination of factors influencing their behaviour 

    Ugwu, Nnenna; Love, Emma; Murrell, Jo; Whay, Helen; Knowles, Toby; Hockenhull, Jo (Elsevier, 2020-11-18)
    The objectives of this study were to investigate the behaviour of hutch-housed dairy calves, develop an ethogram of general behaviour, and determine whether housing calves in different hutches, day, gender and time of day ...
  • Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression 

    Whitton, Laura; Cosgrove, Donna; Clarkson, Christopher; Harold, Denise; Kendall, Kimberley; Richards, Alex; Mantripragada, Kiran; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Hartmann, Annette; Konte, Betina; Rujescu, Dan; Gill, Michael; Corvin, Aiden; Rea, Stephen; Donohoe, Gary; Morris, Derek W. (Wiley, 2016-10-20)
    Epigenetic mechanisms are an important heritable and dynamic means of regulating various genomic functions, including gene expression, to orchestrate brain development, adult neurogenesis, and synaptic plasticity. These ...
  • Genes regulated by BCL11B during T‐cell development are enriched for de novo mutations found in schizophrenia patients 

    Fahey, Laura; Donohoe, Gary; Ó Broin, Pilib; Morris, Derek W. (Wiley, 2020-07-29)
    While abnormal neurodevelopment contributes to schizophrenia (SCZ) risk, there is also evidence to support a role for immune dysfunction in SCZ.BCL11B, associated with SCZ in genome-wide association study (GWAS), is a ...
  • Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function 

    Flynn, Mairéad; Whitton, Laura; Donohoe, Gary; Morrison, Ciaran G.; Morris, Derek W. (Oxford University Press (OUP), 2019-12-23)
    Mutations in genes that encode centrosomal/ciliary proteins cause severe cognitive deficits, while common single-nucleotide polymorphisms in these genes are associated with schizophrenia (SZ) and cognition in genome-wide ...

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