College of Science: Recent submissions
Now showing items 1-20 of 953
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Optical system of aplanatic telescope with a 100 m spherical primary mirror
(Society of Photo-optical Instrumentation Engineers, 2022-06-30)We propose an optical system of an extremely large telescope for ground-based or planetary use. The system comprises a segmented spherical mirror with a diameter of 100 m and f-number of f/1. There are three annular zones ... -
A route to 1-Deoxynojirimycin and 1-Deoxymannojirimycin derivatives with quaternary centers adjacent to the ring nitrogen from Methyl α-d-Mannopyranoside
(Wiley, 2020-02-03)6-Alkylated-8-azido-1,6-octadiene derivatives were prepared from methyl α-D-mannopyranoside. The sequence to allylic azide precursors included a Horner-Wadsworth-Emmons reaction with a concomitant epimerization that ... -
Advanced spectroscopy and APBS modeling for determination of the role of His190 and Trp103 in mouse thymidylate synthase interaction with selected dUMP analogues
(MDPI, 2021-03-06)A homo-dimeric enzyme, thymidylate synthase (TS), has been a long-standing molecular target in chemotherapy. To further elucidate properties and interactions with ligands of wild-type mouse thymidylate synthase (mTS) and ... -
Modelling Förster resonance energy transfer (FRET) using anisotropy resolved multi-dimensional emission spectroscopy (ARMES)
(Elsevier, 2020-11-16)Background Förster Resonance Energy Transfer (FRET) is widely used to study the structure and dynamics of biomolecular systems and also causes the non-linear fluorescence response observed in multi-fluorophore proteins. ... -
Analyzing protein conjugation reactions for antibody-drug conjugate synthesis using polarized excitation emission matrix spectroscopy
(Wiley, 2022-09-07)Antibody-drug conjugates (ADCs) are promising anticancer therapeutics, which offer important advantages compared to more classical therapies. There are a variety of ADC critical quality attributes (CQAs) such as the protein ... -
SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation
(Wiley Open Access and Federation of European Biochemical Societies, 2022-01-24)The initiation of Okazaki fragment synthesis during cellular DNA replication is a crucial step for lagging strand synthesis, which is carried out by the primase function of DNA polymerase ¿-primase (Pol-prim). Since cellular ... -
The Poynting effect
(American Association of Physics Teachers, 2020-11-19)Intuition suggests that twisting a cylinder will shorten it, but here it is shown that for a cylinder of an incompressible material, like rubber, twisting will always produce elongation. -
Mechanical instability tuning of a magnetorheological elastomer composite laminate
(Elsevier, 2022-12-28)Magnetorheological elastomers (MRE) can change their shape and properties when activated by an external magnetic field. The attractive tunable properties of this stimuli-responsive composite can be further amplified by ... -
Lectin microarray profiling demonstrates equivalent global glycosylation for whey protein ingredients enriched with α-lactalbumin and milk fat globule membrane
(Elsevier, 2022-12-22)Human milk fat globule membrane (MFGM) and whey proteins are nutritionally and functionally valuable, with many beneficial bioactivities associated with their glycosylation. However glycosylation of milk components other ... -
Discovery and recovery of an exceptional accumulation of carboniferous echinoids at Hook Head, Wexford
(Royal Irish Academy, 2022-09-30)Geoconservation is a burgeoning area of activity within the Earth sciences and the preservation of significant fossil finds remains crucial for the advancement of palaeontological knowledge and protection of geoheritage. ... -
Framework for developing an exposure science curriculum as part of the European Exposure Science Strategy 2020–2030
(Elsevier, 2022-08-20)Background Evaluating and managing exposures to chemical, physical and biological stressors, which frequently interplay with psychological stressors as well as social and behavioural aspects, is crucial for protecting ... -
Development of a rapid Polarized Total Synchronous Fluorescence Spectroscopy (pTSFS) method for protein quantification in a model bioreactor broth
(Wiley, 2021-01-27)Protein quantification during bioprocess monitoring is essential for biopharmaceutical manufacturing and is complicated by the complex chemical composition of the bioreactor broth. Here we present the early-stage development ... -
Evaluating the interaction of human serum albumin (HSA) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes in different aqueous environments using anisotropy resolved multi-dimensional emission spectroscopy (ARMES)
(Elsevier, 2022-01-07)Studying the interaction between plasma proteins and liposomes is critical, particularly for their use as drug delivery systems. Here, the efficacy of anisotropy resolved multidimensional emission spectroscopy (ARMES) for ... -
Analysis of crude petroleum oils using fluorescence spectroscopy.
(Springer, 2005)Crude oil is defined as a mixture of hydrocarbons that existed in the liquid phase in natural underground reservoirs and remains liquid at atmospheric pressure after passing through surface separating facilities (joint ... -
Halogenated flame retardants in Irish waste polymers: Concentrations, Legislative compliance, and preliminary assessment of temporal trends
(Elsevier, 2022-07-20)Halogenated flame retardants (HFRs) were measured in 470 waste plastic articles from Ireland between 2019 and 2020. We identified articles containing concentrations of polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane ... -
The invisible barrier to safe textile recycling
(Frontiers Media, 2022-06-14)Presence of certain chemical additives (e.g. halogenated flame retardants, perfluoroalkyl substances, and phthalates) could hinder textile recycling operations as their presence renders end-of-life materials as “hazardous” ... -
Indoor air quality, thermal comfort and ventilation in deep energy retrofitted Irish dwellings
(Elsevier, 2022-05-28)Residential building stock energy retrofits will play a key role in EU climate actions. The impact of these retrofits on indoor air quality (IAQ) and occupant comfort needs to be assessed to inform future renovation ... -
Characterization of an amplified piezoelectric actuator for multiple reference optical coherence tomography
(Optica, 2018-08-30)The characterization of an amplified piezoelectric actuator (APA) as a new axial scanning method for multiple-reference optical coherence tomography (MR-OCT) is described. MR-OCT is a compact optical imaging device based ... -
Feasibility of correlation mapping optical coherence tomography angiographic technique using a 200 kHz vertical-cavity surface-emitting laser source for in vivo microcirculation imaging applications
(Optica, 2018-08-01)Optical coherence tomography (OCT) angiography is a well-established in vivo imaging technique to assess the overall vascular morphology of tissues and is an emerging field of research for the assessment of blood flow ... -
Interference method for determination of the refractive index and thickness
(Society of Photo-optical Instrumentation Engineers, 2000-09-01)The interference method for simultaneous measurement of the absolute refractive index and the thickness of plane parallel samples is developed. This method enables us to test solid (including optical glasses, crystals, ...