College of Science: Recent submissions
Now showing items 1-20 of 728
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Rivlin's legacy in continuum mechanics and applied mathematics
(The Royal Society, 2019-03-18)Over a long and distinguished career, Ronald Rivlin (figure 1) published more than 200 scientific papers. He was a highly innovative scientist who made seminal contributions in all areas of continuum mechanics. He was one ... -
Tuning the pull-in instability of soft dielectric elastomers through loading protocols
(Elsevier, 2019-03-22)Pull-in (or electro-mechanical) instability occurs when a drastic decrease in the thickness of a dielectric elastomer results in electrical breakdown, which limits the applications of dielectric devices. Here we derive the ... -
Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
(Elsevier, 2019-02-23)The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ... -
Conversion of gel-forming crystal needles to easily processable more equant crystals Using high-shear ultralow attrition agitation: accelerated Ostwald ripening without crystal attrition
(American Chemical Society, 2019-02-01)We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution ... -
Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid
(Elsevier, 2019-04-19)The coordination of biologically active moieties to the axial positions of Pt(IV) derivatives of Pt(II) anticancer drugs allows the co-delivery and simultaneous activation of two pro-drugs for combination therapy. Pt(IV) ... -
Wrinkles in soft dielectric plates
(Elsevier, 2018-07-04)We show that a smooth giant voltage actuation of soft dielectric plates is not easily obtained in practice. In principle one can exploit, through pre-deformation, the snap-through behavior of their loading curve to deliver ... -
Fine tuning the electro-mechanical response of dielectric elastomers
(AIP Publishing, 2018-10-16)We propose a protocol to model accurately the electromechanical behavior of dielectric elastomer membranes using experimental data of stress-stretch and voltage-stretch tests. We show how the relationship between electric ... -
Effects of nerve bundle geometry on neurotrauma evaluation
(Wiley, 2018-06-16)ObjectiveWe confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage ... -
Finite bending and pattern evolution of the associated instability for a dielectric elastomer slab
(Elsevier, 2018-09-21)We investigate the finite bending and the associated bending instability of an incompressible dielectric slab subject to a combination of applied voltage and axial compression, using nonlinear electro-elasticity theory and ... -
Synthesis of benzoylated beta-D-glucosamine derivatives
(CRC Press / Taylor and Francis Group, 2017-09-19)[No abstract available] -
Ligand design for somatostatin receptor isoforms 4 and 5
(Elsevier, 2018-11-17)The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and ... -
Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation
(Elsevier, 2018-05-26)Lewis acid promoted anomerisation has potential in O- or S-glycoside synthesis. Herein, the anomerisation kinetics of thirty-one β-d-glucopyranosides was determined to determine how particular acyl protecting groups and ... -
Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
(Royal Society of Chemistry, 2018-08-14)The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters ... -
Experimental assessment of MRI-induced temperature change and SAR distributions in phantoms
(NUI Galway, 2017-11-14)During an MR procedure, most of the transmitted RF power is transformed into heat within the patients’ tissue resulting from resistive losses, referred to as the specific energy absorption rate(SAR) (2). The EU standardisation ... -
Snake venom potency and yield are associated with prey‐evolution, predator metabolism and habitat structure
(Wiley, 2019-01-07)Snake venom is well known for its ability to incapacitate and kill prey. Yet, potency and the amount of venom available varies greatly across species, ranging from the seemingly harmless to those capable of killing vast ... -
Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context
(Springer, 2015-11-09)Recognition of glycans by lectins leads to cell adhesion and growth regulation. The specificity and selectivity of this process are determined by carbohydrate structure (sequence and shape) and topology of its presentation. ... -
Anomer preferences for glucuronic and galacturonic acid and derivatives and influence of electron-withdrawing substituents
(American Chemical Society, 2018-07-04)Equilibrium anomeric ratios are reported for pyranoses (hemiacetals) of glucuronic and galacturonic acid and their derivatives. These are compared to related gluco- and galactopyranoses and to deoxyfluorogluco- and ... -
Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
(Springer, 2016-06-24)A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ... -
Advances in rapid compression machine studies of low- and intermediate-temperature autoignition phenomena
(Elsevier, 2017-07-10)Rapid compression machines (RCMs) are widely used to acquire experimental insights into fuel autoignition and pollutant formation chemistry, especially at conditions relevant to current and future combustion technologies. ... -
A chemical kinetic interpretation of the octane appetite of modern gasoline engines
(Elsevier, 2018-06-29)Fuel anti-knock quality is a critical property with respect to the effective design of next-generation spark-ignition engines which aim to have increased efficiency, and lower emissions. Increasing evidence in the literature ...