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Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins
(Royal Society of Chemistry, 2015-02-17)
Emerging insights into the functional spectrum of tissue lectins leads to identification of new targets for the custom-made design of potent inhibitors, providing a challenge for synthetic chemistry. The affinity and ...
On stress-dependent elastic moduli and wave speeds
(Oxford University Press, 2013)
On the basis of the general non-linear theory of a hyperelastic material with initial stress, initially without consideration of the origin of the initial stress, we determine explicit expressions for the stress-dependent ...
Revisiting the kinetics and thermodynamics of the low-temperature oxidation pathways of alkanes: a case study of the three pentane isomers
(American Chemical Society, 2015-03-23)
This paper describes our developing understanding of low-temperature oxidation kinetics. We have investigated the ignition of the three pentane isomers in a rapid compression machine over a wide range of temperatures and ...
Comparison of established diagnostic methodologies and a novel bacterial smpB real-time PCR assay for the specific detection of haemophilus influenzae associated with respiratory tract infections
(American Society for Microbiology, 2015-06-23)
Haemophilus influenzae is a significant causative agent of respiratory tract infections (RTI) worldwide. The development of a
rapid H. influenzae diagnostic assay that would allow for the implementation of infection control ...
On anisotropic elasticity and questions concerning its Finite Element implementation
(Springer, 2013-05-21)
We give conditions on the strain-energy function of nonlinear anisotropic hyperelastic materials that ensure compatibility with the classical linear theories of anisotropic elasticity. We uncover the limitations associated ...
A combined experimental and numerical study of stab-penetration forces
(Elsevier, 2013-12)
The magnitude of force used in a stabbing incident can be difficult to quantify, although the estimate given by forensic pathologists is often seen as 'critical' evidence in medico-legal situations. The main objective of ...
Mechanical characterization of brain tissue in simple shear at dynamic strain rates
(Elsevier, 2013-12)
During severe impact conditions, brain tissue experiences a rapid and complex deformation, which can be seen as a mixture of compression, tension and shear. Diffuse axonal injury (DAI) occurs in animals and humans when ...
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
(Nature Publishing Group, 2014-05-01)
Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ...
Deficiencies in numerical models of anisotropic nonlinearly elastic materials
(Springer, 2013-08)
Incompressible nonlinearly hyperelastic materials are rarely simulated in finite element numerical experiments as being perfectly incompressible because of the numerical difficulties associated with globally satisfying ...
At least three invariants are necessary to model the mechanical response of incompressible, transversely isotropic materials
(Springer, 2013-04-18)
The modelling of off-axis simple tension experiments on transversely isotropic nonlinearly elastic materials is considered. A testing protocol is proposed where normal force is applied to one edge of a rectangular specimen ...