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Ulk4 is essential for ciliogenesis and csf flow
(Society for Neuroscience, 2016-07-20)
Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three ...
5-hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due tostaphylococcus aureus
(Oxford University Press (OUP), 2016-12-20)
Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential ...
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
(Springer Nature, 2016-06-21)
Background: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk.
Method: We performed a fine-scale ...
Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in sprague-dawley rats
(Wiley-Blackwell, 2016-11-11)
In addition to its role in regulating energy homeostasis, the adipokine leptin modifies gastrointestinal (GI) function. Indeed, leptin-resistant obese humans and leptin-deficient obese mice exhibit altered GI motility. In ...
Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity
(Springer Nature, 2016-03-11)
In this study, on/off markers for intervertebral disc (IVD) and articular cartilage (AC) cells (chondrocytes) and distinct glycoprofiles of cell and tissue-types were identified from immaturity to maturity. Three and eleven ...
Subclinical detection of diabetic cardiomyopathy with micrornas: challenges and perspectives
(Hindawi Limited, 2016-01-01)
The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a ...
Loss of sigb in listeria monocytogenes strains egd-e and 10403s confers hyperresistance to hydrogen peroxide in stationary phase under aerobic conditions
(American Society for Microbiology, 2016-05-20)
SigB is the main stress gene regulator in Listeria monocytogenes affecting the expression of more than 150 genes and thus contributing to multiple-stress resistance. Despite its clear role in most stresses, its role in ...
The major autolysin is redundant forstaphylococcus aureususa300 lac je2 virulence in a murine device-related infection model
(Oxford University Press (OUP), 2016-04-03)
The major Staphylococcus aureus autolysin, Atl, has been implicated in attachment to surfaces and release of extracellular DNA during biofilm formation under laboratory conditions. Consistent with this, polyclonal antibodies ...
Exploring circulating micro-rna in the neoadjuvant treatment of breast cancer
(Wiley-Blackwell, 2016-01-30)
Breast cancer is the most frequently diagnosed malignancy amongst females worldwide. In recent years the management of this disease has transformed considerably, including the administration of chemotherapy in the neoadjuvant ...
Macromolecular crowding meets oxygen tension in human mesenchymal stem cell culture - a step closer to physiologically relevant in vitro organogenesis
(Springer Nature, 2016-08-01)
Modular tissue engineering is based on the cells' innate ability to create bottom-up supramolecular assemblies with efficiency and efficacy still unmatched by man-made devices. Although the regenerative potential of such ...