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Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in sprague-dawley rats

Buckley, Maria M.; O'Brien, Rebecca; Devlin, Michelle; Creed, Aisling A.; Rae, Mark G.; Hyland, Niall P.; Quigley, Eamonn M. M.; McKernan, Declan P.; O'Malley, Dervla (Wiley-Blackwell, 2016-11-11)

In addition to its role in regulating energy homeostasis, the adipokine leptin modifies gastrointestinal (GI) function. Indeed, leptin-resistant obese humans and leptin-deficient obese mice exhibit altered GI motility. In ...

Ncoa3 coactivator is a transcriptional target of xbp1 and regulates perk–eif2α–atf4 signalling in breast cancer

Gupta, A; Hossain, M M; Miller, N; Kerin, M; Callagy, G; Gupta, S (Springer Nature, 2016-04-25)

XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about ...