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Now showing items 11-15 of 15
The pyrrolo-1,5-benzoxazepine, pbox-15, enhances trail-induced apoptosis by upregulation of dr5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells
(Spandidos Publications, 2016-05-11)
Apoptotic defects are frequently associated with poor outcome in pediatric acute lymphoblastic leukaemia (ALL) hence there is an ongoing demand for novel strategies that counteract apoptotic resistance. The death ligand ...
Ncoa3 coactivator is a transcriptional target of xbp1 and regulates perk–eif2α–atf4 signalling in breast cancer
(Springer Nature, 2016-04-25)
XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about ...
Eradication of staphylococcus aureus catheter-related biofilm infections using ml:8 and citrox
(American Society for Microbiology, 2016-07-25)
Staphylococci are a leading cause of catheter-related infections (CRIs) due to biofilm formation. CRIs are typically managed by either device removal or systemic antibiotics, often in combination with catheter lock solutions ...
Cancer diagnostics via ultrasensitive multiplexed detection of parathyroid hormone-related peptides with a microfluidic immunoarray
(American Chemical Society (ACS), 2016-09-20)
Parathyroid, hormone-related peptide (PTHrP) is recognized as the-Major causative agent of humoral hypercalcemia of malignancy (HHM). The paraneoplastic PTHrP has also been implicated in tumor progression and metastasis ...
Fasciola hepaticasurface tegument: glycoproteins at the interface of parasite and host
(American Society for Biochemistry & Molecular Biology (ASBMB), 2016-07-27)
Fasciola hepatica, commonly known as liver fluke, is a trematode that causes Fasciolosis in ruminants and humans. The outer tegumental coat of F. hepatica (FhTeg) is a complex metabolically active biological matrix that ...