Search
Now showing items 51-60 of 76
Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models
(2004-03-05)
This work explores a new approach to gene-prediction, based on the Self-Organizing Map, which has the ability to automatically identify multiple gene models within a genome. The current implementation, named RescueNet, ...
Global gene expression analysis of the effects of Vinblastine on endothelial cells, when eluted from a thermo-responsive polymer
(Wiley Online Library, 2006-06-30)
In-stent restenosis remains a significant problem associated with bare metal stents. This drawback has prompted research into improving stent design and the development of novel coatings, including drug-eluting stents. A ...
Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy
(2013)
Background: Obesity is becoming an increasing problem in obstetric practice; it has led to an increase in the risk of caesarean delivery, prolonged pregnancy and dysfunctional labour. It has been postulated that many of ...
Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the BKCa channel
(2003)
The uterorelaxant effect of human chorionic gonadotropin (hCG) is regarded as an important mediator in maintenance of uterine quiescence during pregnancy with clinical potential for tocolysis, the mechanisms of which are ...
Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells
(BioMed Central, 2012-01-20)
Background: The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid ...
Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction
(Society for Reproduction and Fertility, 2006-07-01)
Pre eclampsia represents a state of increased or prolonged vasoconstriction, partially linked to the potent vasocontractile effect of isoprostanes. The process of Rho A-mediated calcium sensitisation is inherent to a state ...
Solvent-selective routing for centrifugally automated solid-phase purification of RNA.
(Springer, 2014-09-12)
We present a disc-based module for rotationally controlled solid-phase purification of RNA from cell lysate. To this end, multi-stage routing of a sequence of aqueous and organic liquids into designated waste and elution ...
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
(National Academy Of Sciences Of The United States Of America, 2013-10-23)
Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were originally discovered in Oldenlandia affinis based on their use in ...
Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes
(Endocrine Society, 2005-07-02)
Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role in modulating cell membrane potential and ...
Transcription factor binding site identification using the Self-Organizing Map
(Oxford Open Journals, 2005-05-01)
Motivation: The automatic identification of over-represented motifs present in a collection of sequences continues to be a challenging problem in computational biology. In this paper, we propose a self-organizing map of ...