Browsing CÚRAM - Centre for Research in Medical Devices (Scholarly Articles) by Title
Now showing items 13-32 of 39
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Electric field stimulation for tissue engineering applications
(BMC (part of Springer Nature), 2021-01-05)Electric fields are involved in numerous physiological processes, including directional embryonic development and wound healing following injury. To study these processes in vitro and/or to harness electric field stimulation ... -
Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: Cytocompatibility and electrochemical studies
(Elsevier, 2019-02-06)Conducting polymers have been extensively reported as promising coating materials for applications involving interactions with electrically excitable tissues. Specifically, metal electrodes functionalized with conducting ... -
Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions
(Elsevier, 2018-09-08)Conducting polymers are versatile and robust materials that have recently become attractive as controlled drug delivery systems. Possessing ion exchangeable properties, they can serve as carriers for numerous biologically ... -
Fibrin as a scaffold for delivery of GDNF overexpressing stem cells to the adult rat brain
(2017-04-05)Treatment of neurodegenerative disease is entering a new era where direct intracerebral delivery of therapeutic factors aims to restore normality to dysfunctional circuits. Cell-based therapeutic approaches, where virally ... -
Fractal form PEDOT/Au assemblies as thin-film neural interface materials
(IOP Publishing, 2018-06-04)Electrically conducting polymer formulations have emerged as promising approaches for the development of interfaces and scaffolds in neural engineering, facilitating the development of physicochemically modified constructs ... -
Gene expression profiling identifies interferon signalling molecules and IGFBP3 in human degenerative annulus fibrosus
(Nature Publishing Group:, 2015-10-22)Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies fail to replace the ... -
A glycotherapeutic approach to functionalize biomaterials-based systems
(Wiley, 2020-03-18)In addition to being one of the primary building block materials of living cells, glycans are also favorable candidates for therapeutic applications. In the mid-20th century, the progress of glycans in the drug discovery ... -
High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke
(BMJ Publishing Group, 2020-12-23)Background: Characterization of acute ischemic stroke (AIS) clots has typically focused on two dimensional histological analysis of the thrombus. The three dimensional (3D) architecture and distribution of components ... -
Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy
(BMJ Publishing Group, 2021-05-11)Background Several animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following ... -
Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1 beta induced inflammation model of nucleus pulposus cells
(American Chemical Society, 2015-04-14)Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) ... -
Hypoxia preconditioning of bone marrow mesenchymal stem cells before implantation in orthopaedics
(Lippincott, Williams & Wilkins, 2019-12-01)[No abstract available] -
In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations
(Elsevier, 2020-04-08)Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen ... -
An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia
(Elsevier, 2015-10)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ... -
Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
(Springer Verlag, 2018-07-31)The 4th Translational Research Symposium (TRS) was organised at the annual meeting of the European Society for Biomaterials (ESB) 2017, Athens, Greece, with a focus on ‘Academia—Industry Clusters of Research for Innovation ... -
Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs
(Elsevier, 2019-06-19)The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ... -
Low resistance, highly corrugated structures based on poly(3,4-ethylenedioxythiophene) doped with a d-glucopyranoside-derived ionic liquid
(Elsevier, 2019-12-02)Conjugated polymers have gained significant interest as highly conducting organic materials with versatile surface morphology. In this study, we demonstrate that the electrodeposition of poly(3,4-ethylenedioxythiophene), ... -
Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
(Nature Publishing Group, 2015-03-04)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Microwave ablation antenna for functional adenomas in the adrenal gland
(IEEE, 2020-03-02)Microwave thermal ablation has been thoroughly investigated in the last decades. However, new challenges for this technology are nowadays represented by specific applications. The present work investigates a promising ... -
Preparation and characterization of tissue surrogates rich in extracellular matrix using the principles of macromolecular crowding
(Humana Press, 2019-03)Tissue engineering by self-assembly allows for the fabrication of living tissue surrogates by taking advantage of the cell's inherent ability to produce and deposit tissue-specific extracellular matrix. However, the long ... -
Recent advances in host–guest self‐assembled cyclodextrin carriers: Implications for responsive drug delivery and biomedical engineering
(Wiley, 2020-02-05)This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical ...