Browsing CÚRAM - Centre for Research in Medical Devices (Scholarly Articles) by Issue Date
Now showing items 1-20 of 39
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Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
(Nature Publishing Group, 2015-03-04)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1 beta induced inflammation model of nucleus pulposus cells
(American Chemical Society, 2015-04-14)Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) ... -
An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia
(Elsevier, 2015-10)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ... -
Gene expression profiling identifies interferon signalling molecules and IGFBP3 in human degenerative annulus fibrosus
(Nature Publishing Group:, 2015-10-22)Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies fail to replace the ... -
Fibrin as a scaffold for delivery of GDNF overexpressing stem cells to the adult rat brain
(2017-04-05)Treatment of neurodegenerative disease is entering a new era where direct intracerebral delivery of therapeutic factors aims to restore normality to dysfunctional circuits. Cell-based therapeutic approaches, where virally ... -
Biophysics rules the cell culture but has yet to reach the clinic: Why is that?
(Lippincott, Williams & Wilkins, 2017-07)Musculoskeletal injuries are the leading cause of physical disability worldwide, with associated annual direct and indirect healthcare expenditure in excess of $874 billion in the United States alone.1 Current treatments ... -
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
(Nature Publishing Group, 2017-10-13)Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these ... -
Advancements and challenges in multidomain multicargo delivery vehicles
(Wiley, 2018-02-15)Reparative and regenerative processes are well‐orchestrated temporal and spatial events that are governed by multiple cells, molecules, signaling pathways, and interactions thereof. Yet again, currently available ... -
Fractal form PEDOT/Au assemblies as thin-film neural interface materials
(IOP Publishing, 2018-06-04)Electrically conducting polymer formulations have emerged as promising approaches for the development of interfaces and scaffolds in neural engineering, facilitating the development of physicochemically modified constructs ... -
Wound healing and scar wars
(Elsevier, 2018-06-15)Wound healing and scarring are highly conserved physiological responses to wounding in most tissues in higher organisms, consisting of a sequence of well-characterised stages (coagulation, inflammation, proliferation and ... -
Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
(Springer Verlag, 2018-07-31)The 4th Translational Research Symposium (TRS) was organised at the annual meeting of the European Society for Biomaterials (ESB) 2017, Athens, Greece, with a focus on ‘Academia—Industry Clusters of Research for Innovation ... -
The chemistry and topography of stabilized and functionalized graphene oxide coatings
(Wiley, 2018-08-01)Graphene oxide (GO) thin films and coatings are regarded as superior in quality to other materials especially for biomedical applications. However, the lack of stability and understanding of their structure and defects ... -
The collagen suprafamily: From biosynthesis to advanced biomaterial development
(Wiley, 2018-08-20)Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their ... -
Chirality-sorted carbon nanotube films as high capacity electrode materials
(Royal Society of Chemistry, 2018-08-30)Carbon nanomaterials show great promise for a wide range of applications due to their excellent physicochemical and electrical properties. Since their discovery, the state-of-the-art has expanded the scope of their application ... -
Current and upcoming therapies to modulate skin scarring and fibrosis
(Elsevier, 2018-08-30)Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response ... -
Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions
(Elsevier, 2018-09-08)Conducting polymers are versatile and robust materials that have recently become attractive as controlled drug delivery systems. Possessing ion exchangeable properties, they can serve as carriers for numerous biologically ... -
Self-supporting carbon nanotube films as flexible neural interfaces
(Elsevier, 2018-10-26)Advances in neural interface technologies have sought to identify electroactive materials that are able to translate neural depolarisation events into digital signals or modulate neural firing through ionic or electrical ... -
Design and characterization of synthetic biodegradable films for soft tissue engineering
(SciTePress, 2019)To repair soft tissue, it is vital to ensure that the biomaterial is able to mimic the complex elasticity of the native tissue. Substrate stiffness has a huge influence on cell physiology and behaviour. The present study ... -
The synergistic effects of gold particles and dexamethasone on the electrochemical and biological performance of PEDOT neural interfaces
(MDPI, 2019-01-05)Although neural devices have shown efficacy in the treatment of neurodegenerative diseases, their functionality is limited by the inflammatory state and glial scar formation associated with chronic implantation. The aim ... -
Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: Cytocompatibility and electrochemical studies
(Elsevier, 2019-02-06)Conducting polymers have been extensively reported as promising coating materials for applications involving interactions with electrically excitable tissues. Specifically, metal electrodes functionalized with conducting ...