dc.contributor.author | Connolly, Alison | |
dc.contributor.author | Koslitz, Stephan | |
dc.contributor.author | Bury, Daniel | |
dc.contributor.author | Brüning, Thomas | |
dc.contributor.author | Conrad, André | |
dc.contributor.author | Kolossa-Gehring, Marike | |
dc.contributor.author | Coggins, Marie A. | |
dc.contributor.author | Koch, Holger M. | |
dc.date.accessioned | 2020-09-01T15:38:41Z | |
dc.date.available | 2020-09-01T15:38:41Z | |
dc.date.issued | 2020-08-26 | |
dc.identifier.citation | Connolly, Alison, Koslitz, Stephan, Bury, Daniel, Brüning, Thomas, Conrad, André, Kolossa-Gehring, Marike, Coggins, Marie A., Koch, Holger M. (2020). Sensitive and selective quantification of glyphosate and aminomethylphosphonic acid (AMPA) in urine of the general population by gas chromatography-tandem mass spectrometry. Journal of Chromatography B, 122348. doi:https://doi.org/10.1016/j.jchromb.2020.122348 | en_IE |
dc.identifier.issn | 1570-0232 | |
dc.identifier.uri | http://hdl.handle.net/10379/16153 | |
dc.description.abstract | Glyphosate is the highest volume herbicide used worldwide, and its main biodegradation product is
aminomethylphosphonic acid (AMPA), both are listed as priority substances in the Human Biomonitoring for Europe
initiative (HBM4EU) which aims at improving policy by filling knowledge gaps by targeted research. The objective of
the current study was to advance the sensitivity of an existing gas-chromatography tandem mass spectrometry
analytical method to measure environmental population exposures. A 50% lower limit of quantification of 0.05 µg/L
was achieved for both analytes by slight modifications in sample work-up, and use of another isotope labelled internal
standard. In a pilot study on 41 urine samples from the general German population, glyphosate and AMPA could be
quantified in 66% and 90% of the samples respectively, which is a sufficient number to reliably describe distributions of
urinary concentrations in the non-occupationally exposed population | en_IE |
dc.description.sponsorship | This project has received funding from the Irish Research Council and from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713279. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Elsevier | en_IE |
dc.relation.ispartof | Journal of Chromatography B | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Glyphosate | en_IE |
dc.subject | Aminomethylphosphonic acid | en_IE |
dc.subject | AMPA | en_IE |
dc.subject | Urine | en_IE |
dc.subject | human biomonitoring | en_IE |
dc.subject | environmental exposures | en_IE |
dc.title | Sensitive and selective quantification of glyphosate and aminomethylphosphonic acid (AMPA) in urine of the general population by gas chromatography-tandem mass spectrometry | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2020-09-01T14:51:49Z | |
dc.identifier.doi | 10.1016/j.jchromb.2020.122348 | |
dc.local.publishedsource | https://doi.org/10.1016/j.jchromb.2020.122348 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | Irish Research Council | en_IE |
dc.contributor.funder | Horizon 2020 | en_IE |
dc.internal.rssid | 22320987 | |
dc.local.contact | Marie Coggins, School Of Physics, Room 212, Arts/Science Building, Nui Galway. 5056 Email: marie.coggins@nuigalway.ie | |
dc.local.copyrightchecked | Yes - open access article | |
dc.local.version | ACCEPTED | |
dcterms.project | info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713279/EU/Collaborative Research Fellowships for a Responsive and Innovative Europe/CAROLINE | en_IE |
nui.item.downloads | 119 | |