Sensitive and selective quantification of glyphosate and aminomethylphosphonic acid (AMPA) in urine of the general population by gas chromatography-tandem mass spectrometry
Date
2020-08-26Author
Connolly, Alison
Koslitz, Stephan
Bury, Daniel
Brüning, Thomas
Conrad, André
Kolossa-Gehring, Marike
Coggins, Marie A.
Koch, Holger M.
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Connolly, Alison, Koslitz, Stephan, Bury, Daniel, Brüning, Thomas, Conrad, André, Kolossa-Gehring, Marike, Coggins, Marie A., Koch, Holger M. (2020). Sensitive and selective quantification of glyphosate and aminomethylphosphonic acid (AMPA) in urine of the general population by gas chromatography-tandem mass spectrometry. Journal of Chromatography B, 122348. doi:https://doi.org/10.1016/j.jchromb.2020.122348
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Abstract
Glyphosate is the highest volume herbicide used worldwide, and its main biodegradation product is
aminomethylphosphonic acid (AMPA), both are listed as priority substances in the Human Biomonitoring for Europe
initiative (HBM4EU) which aims at improving policy by filling knowledge gaps by targeted research. The objective of
the current study was to advance the sensitivity of an existing gas-chromatography tandem mass spectrometry
analytical method to measure environmental population exposures. A 50% lower limit of quantification of 0.05 µg/L
was achieved for both analytes by slight modifications in sample work-up, and use of another isotope labelled internal
standard. In a pilot study on 41 urine samples from the general German population, glyphosate and AMPA could be
quantified in 66% and 90% of the samples respectively, which is a sufficient number to reliably describe distributions of
urinary concentrations in the non-occupationally exposed population