dc.contributor.author | Du, Yangkun | |
dc.contributor.author | Lü, Chaofeng | |
dc.contributor.author | Destrade, Michel | |
dc.contributor.author | Chen, Weiqiu | |
dc.date.accessioned | 2019-06-24T09:51:05Z | |
dc.date.available | 2019-06-24T09:51:05Z | |
dc.date.issued | 2019-06-03 | |
dc.identifier.citation | Du, Yangkun, Lü, Chaofeng, Destrade, Michel, & Chen, Weiqiu. (2019). Influence of Initial Residual Stress on Growth and Pattern Creation for a Layered Aorta. Scientific Reports, 9(1), 8232. doi: 10.1038/s41598-019-44694-2 | en_IE |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10379/15248 | |
dc.description.abstract | Residual stress is ubiquitous and indispensable in most biological and artificial materials, where it sustains and optimizes many biological and functional mechanisms. The theory of volume growth, starting from a stress-free initial state, is widely used to explain the creation and evolution of growth-induced residual stress and the resulting changes in shape, and to model how growing bio-tissues such as arteries and solid tumors develop a strategy of pattern creation according to geometrical and material parameters. This modelling provides promising avenues for designing and directing some appropriate morphology of a given tissue or organ and achieve some targeted biomedical function. In this paper, we rely on a modified, augmented theory to reveal how we can obtain growth-induced residual stress and pattern evolution of a layered artery by starting from an existing, non-zero initial residual stress state. We use experimentally determined residual stress distributions of aged bi-layered human aortas and quantify their influence by a magnitude factor. Our results show that initial residual stress has a more significant impact on residual stress accumulation and the subsequent evolution of patterns than geometry and material parameters. Additionally, we provide an essential explanation for growth-induced patterns driven by differential growth coupled to an initial residual stress. Finally, we show that initial residual stress is a readily available way to control growth-induced pattern creation for tissues and thus may provide a promising inspiration for biomedical engineering. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Nature Research | en_IE |
dc.relation.ispartof | Scientific Reports | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | TISSUE-GROWTH | en_IE |
dc.subject | SOLID STRESS | en_IE |
dc.subject | ARTERIES | en_IE |
dc.subject | STRAIN | en_IE |
dc.subject | MODEL | en_IE |
dc.subject | LAWS | en_IE |
dc.title | Influence of initial residual stress on growth and pattern creation for a layered aorta | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2019-06-23T07:24:44Z | |
dc.identifier.doi | 10.1038/s41598-019-44694-2 | |
dc.local.publishedsource | https://dx.doi.org/10.1038/s41598-019-44694-2 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.internal.rssid | 16553920 | |
dc.local.contact | Michel Destrade, Room Adb-1002, Áras De Brun, School Of Mathematics, Nui Galway. 2344 Email: michel.destrade@nuigalway.ie | |
dc.local.copyrightchecked | Yes open access paper | |
dc.local.version | PUBLISHED | |
nui.item.downloads | 171 | |