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dc.contributor.authorCinelli, Ilaria
dc.contributor.authorDestrade, Michel
dc.contributor.authorMcHugh, Peter
dc.contributor.authorDuffy, Maeve
dc.date.accessioned2019-06-04T14:17:21Z
dc.date.issued2018-06-16
dc.identifier.citationCinelli, Ilaria, Destrade, Michel, McHugh, Peter, & Duffy, Maeve. (2018). Effects of nerve bundle geometry on neurotrauma evaluation. International Journal for Numerical Methods in Biomedical Engineering, 34(9), e3118. doi: 10.1002/cnm.3118en_IE
dc.identifier.issn2040-7947
dc.identifier.urihttp://hdl.handle.net/10379/15205
dc.description.abstractObjectiveWe confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage of a neuron structure in 2 scaled nerve bundle models, made of myelinated nerve fibers or unmyelinated nerve fibers.MethodsWe propose a 3D finite element model of nerve bundles, combining a real-time full electromechanical coupling, a modulated threshold for spiking activation, and independent alteration of the electrical properties for each fiber. With the inclusion of plasticity, we then simulate mechanical compression and tension to induce damage at the membrane of a nerve bundle made of 4 fibers. We examine the resulting changes in strain and neural activity by considering in turn the cases of intact and traumatized nerve membranes.ResultsOur results show lower strain and lower electrophysiological impairments in unmyelinated fibers than in myelinated fibers, higher deformation levels in larger bundles, and higher electrophysiological impairments in smaller bundles.ConclusionWe conclude that the insulation sheath of myelin constricts the membrane deformation and scatters plastic strains within the bundle, that larger bundles deform more than small bundles, and that small fibers tolerate a higher level of elongation before mechanical failure.en_IE
dc.description.sponsorshipWe gratefully acknowledge funding from the Galway University Foundation, the Biomechanics Research Centre, and the Power Electronics Research Centre, College of Engineering and Informatics at NUI Galway.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherWileyen_IE
dc.relation.ispartofInternational Journal For Numerical Methods In Biomedical Engineeringen
dc.subjectcoupled electromechanical modelingen_IE
dc.subjectdiffuse axonal injuryen_IE
dc.subjectelectrothermal equivalenceen_IE
dc.subjectfinite element modelingen_IE
dc.subjectneurotraumaen_IE
dc.subjectTRAUMATIC BRAIN-INJURYen_IE
dc.subjectSPINAL-CORD AXONSen_IE
dc.subjectSQUID GIANT-AXONen_IE
dc.subjectWHITE-MATTERen_IE
dc.subjectMECHANICAL STRETCHen_IE
dc.subjectCORPUS-CALLOSUMen_IE
dc.subjectSTRAINen_IE
dc.subjectMICROENVIRONMENTen_IE
dc.subjectMYELINATIONen_IE
dc.subjectMAGNITUDEen_IE
dc.titleEffects of nerve bundle geometry on neurotrauma evaluationen_IE
dc.typeArticleen_IE
dc.date.updated2019-05-29T16:15:02Z
dc.identifier.doi10.1002/cnm.3118
dc.local.publishedsourcehttps://doi.org/10.1002/cnm.3118en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderGalway University Foundationen_IE
dc.contributor.funderCollege of Engineering and Informatics, National University of Ireland, Galwayen_IE
dc.contributor.funderBiomechanics Research Centreen_IE
dc.contributor.funderPower Electronics Research Centreen_IE
dc.description.embargo2019-06-16
dc.internal.rssid14977205
dc.local.contactMichel Destrade, Room Adb-1002, Áras De Brun, School Of Mathematics, Nui Galway. 2344 Email: michel.destrade@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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