dc.contributor.author | Cinelli, Ilaria | |
dc.contributor.author | Destrade, Michel | |
dc.contributor.author | McHugh, Peter | |
dc.contributor.author | Duffy, Maeve | |
dc.date.accessioned | 2019-06-04T14:17:21Z | |
dc.date.issued | 2018-06-16 | |
dc.identifier.citation | Cinelli, Ilaria, Destrade, Michel, McHugh, Peter, & Duffy, Maeve. (2018). Effects of nerve bundle geometry on neurotrauma evaluation. International Journal for Numerical Methods in Biomedical Engineering, 34(9), e3118. doi: 10.1002/cnm.3118 | en_IE |
dc.identifier.issn | 2040-7947 | |
dc.identifier.uri | http://hdl.handle.net/10379/15205 | |
dc.description.abstract | ObjectiveWe confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage of a neuron structure in 2 scaled nerve bundle models, made of myelinated nerve fibers or unmyelinated nerve fibers.MethodsWe propose a 3D finite element model of nerve bundles, combining a real-time full electromechanical coupling, a modulated threshold for spiking activation, and independent alteration of the electrical properties for each fiber. With the inclusion of plasticity, we then simulate mechanical compression and tension to induce damage at the membrane of a nerve bundle made of 4 fibers. We examine the resulting changes in strain and neural activity by considering in turn the cases of intact and traumatized nerve membranes.ResultsOur results show lower strain and lower electrophysiological impairments in unmyelinated fibers than in myelinated fibers, higher deformation levels in larger bundles, and higher electrophysiological impairments in smaller bundles.ConclusionWe conclude that the insulation sheath of myelin constricts the membrane deformation and scatters plastic strains within the bundle, that larger bundles deform more than small bundles, and that small fibers tolerate a higher level of elongation before mechanical failure. | en_IE |
dc.description.sponsorship | We gratefully acknowledge funding from the Galway University Foundation, the Biomechanics Research Centre, and the Power Electronics Research Centre, College of Engineering and Informatics at NUI Galway. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Wiley | en_IE |
dc.relation.ispartof | International Journal For Numerical Methods In Biomedical Engineering | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | coupled electromechanical modeling | en_IE |
dc.subject | diffuse axonal injury | en_IE |
dc.subject | electrothermal equivalence | en_IE |
dc.subject | finite element modeling | en_IE |
dc.subject | neurotrauma | en_IE |
dc.subject | TRAUMATIC BRAIN-INJURY | en_IE |
dc.subject | SPINAL-CORD AXONS | en_IE |
dc.subject | SQUID GIANT-AXON | en_IE |
dc.subject | WHITE-MATTER | en_IE |
dc.subject | MECHANICAL STRETCH | en_IE |
dc.subject | CORPUS-CALLOSUM | en_IE |
dc.subject | STRAIN | en_IE |
dc.subject | MICROENVIRONMENT | en_IE |
dc.subject | MYELINATION | en_IE |
dc.subject | MAGNITUDE | en_IE |
dc.title | Effects of nerve bundle geometry on neurotrauma evaluation | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2019-05-29T16:15:02Z | |
dc.identifier.doi | 10.1002/cnm.3118 | |
dc.local.publishedsource | https://doi.org/10.1002/cnm.3118 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | Galway University Foundation | en_IE |
dc.contributor.funder | College of Engineering and Informatics, National University of Ireland, Galway | en_IE |
dc.contributor.funder | Biomechanics Research Centre | en_IE |
dc.contributor.funder | Power Electronics Research Centre | en_IE |
dc.description.embargo | 2019-06-16 | |
dc.internal.rssid | 14977205 | |
dc.local.contact | Michel Destrade, Room Adb-1002, Áras De Brun, School Of Mathematics, Nui Galway. 2344 Email: michel.destrade@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 278 | |