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Wound healing and scar wars

dc.contributor.authorPugliese, Eugenia
dc.contributor.authorCoentro, João Q.
dc.contributor.authorRaghunath, Michael
dc.contributor.authorZeugolis, Dimitrios I.
dc.date.accessioned2019-04-11T14:10:41Z
dc.date.issued2018-06-15
dc.identifier.citationPugliese, Eugenia, Coentro, João Q., Raghunath, Michael, & Zeugolis, Dimitrios I. (2018). Wound healing and scar wars. Advanced Drug Delivery Reviews, 129, 1-3. doi: https://doi.org/10.1016/j.addr.2018.05.010en_IE
dc.identifier.issn1872-8294
dc.identifier.urihttp://hdl.handle.net/10379/15113
dc.description.abstractWound healing and scarring are highly conserved physiological responses to wounding in most tissues in higher organisms, consisting of a sequence of well-characterised stages (coagulation, inflammation, proliferation and remodelling [[1], [2], [3]]), with the aim to repair interrupted tissue structures and to restore tissue function [4]. However, this sequence can come to a halt before completion resulting in undesired outcomes, ranging from the formation of a large local scar to organ-encompassing fibrosis. Whilst the former causes cosmetic annoyance, the latter might lead to grave functional impairment or to chronic non-healing wounds.en_IE
dc.description.sponsorshipThe authors would like to acknowledge for financial support the: Science Foundation Ireland, Career Development Award (Grant Agreement Number: 15/CDA/3629); Science Foundation Ireland / European Regional Development Fund (Grant Agreement Number: 13/RC/2073); H2020, Marie Skłodowska-Curie Actions, Innovative Training Networks 2015 Tendon Therapy Train project (Grant Agreement Number: 676338). The authors would also like to thank Mr Maciek Doczyk for designing Figure 1.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofAdvanced Drug Delivery Reviewsen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectWound healingen_IE
dc.subjectFibrosisen_IE
dc.subjectScaren_IE
dc.titleWound healing and scar warsen_IE
dc.typeArticleen_IE
dc.date.updated2019-04-10T18:02:35Z
dc.identifier.doi10.1016/j.addr.2018.05.010
dc.local.publishedsourcehttps://doi.org/10.1016/j.addr.2018.05.010en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.contributor.funderHorizon 2020en_IE
dc.description.embargo2019-06-15
dc.internal.rssid16167612
dc.local.contactJoão Coentro, Remodel, Cúram, Biomedical Sciences Building, Newcastle Road, Dangan, Nui Galway. - Email: j.quintascoentro1@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Career Development Award/15/CDA/3629/IE/Tissue Engineered Nanoassemblies _ Advanced Biomimicry of Living Equivalents (Short Title: TENABLE)/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-ITN-ETN/676338/EU/Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair/Tendon Therapy Trainen_IE
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