Wound healing and scar wars
Coentro, João Q.
Zeugolis, Dimitrios I.
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Pugliese, Eugenia, Coentro, João Q., Raghunath, Michael, & Zeugolis, Dimitrios I. (2018). Wound healing and scar wars. Advanced Drug Delivery Reviews, 129, 1-3. doi: https://doi.org/10.1016/j.addr.2018.05.010
Wound healing and scarring are highly conserved physiological responses to wounding in most tissues in higher organisms, consisting of a sequence of well-characterised stages (coagulation, inflammation, proliferation and remodelling [, , ]), with the aim to repair interrupted tissue structures and to restore tissue function . However, this sequence can come to a halt before completion resulting in undesired outcomes, ranging from the formation of a large local scar to organ-encompassing fibrosis. Whilst the former causes cosmetic annoyance, the latter might lead to grave functional impairment or to chronic non-healing wounds.