Search
Now showing items 1-10 of 53
Solid-state transformations of sulfathiazole polymorphs: The effects of milling and humidity
(American Chemical Society, 2013-07-11)
The effect of milling on the transitions of sulfathiazole polymorphs in the absence and presence of solvent and excipients was monitored by X-ray powder diffraction (XRPD), attenuated total reflectance infrared (ATR-IR), ...
Prediction of Cell Culture Media Performance Using Fluorescence Spectroscopy
(2010)
Cell culture media used in industrial mammalian cell culture are complex aqueous solutions that are inherently difficult to analyze comprehensively. The analysis of media quality and variance is of utmost importance in ...
Applications of raman spectroscopy in biopharmaceutical manufacturing: A short review
(Sage Publications, 2017-05-23)
The production of active pharmaceutical ingredients (APIs) is currently undergoing its biggest transformation in a century.
The changes are based on the rapid and dramatic introduction of protein- and macromolecule-based ...
Classification of narcotics in solid mixtures using principal component analysis and Raman spectroscopy
(ASTM International, 2002-03-01)
Eighty-five solid samples consisting of illegal narcotics diluted with several different materials were analyzed by near-infrared (785 nm excitation) Raman spectroscopy. Principal Component Analysis (PCA) was employed to ...
Kernel principal component analysis residual diagnosis (KPCARD): an automated method to remove cosmic ray artefacts in Raman spectra.
(2016)
A new, fully automated, rapid method, referred to as kernel principal component analysis residual diagnosis (KPCARD), is proposed for removing cosmic ray artifacts (CRAs) in Raman spectra, and in particular for large Raman ...
Surface enhanced Raman scattering for narcotic detection and applications to chemical biology
(Elsevier, 2005)
Raman spectroscopy is rapidly finding favour for applications in the life science because of the ease with which it can be used to extract significant data from tissue and cells. However, the Raman effect is an inherently ...
Chemometric approaches to low-content quantification (LCQ) in solid-state mixtures using Raman mapping spectroscopy.
(Royal Society of Chemistry, 2017-10-30)
The low-content quantification (LCQ) of active pharmaceutical ingredients or impurities in solid mixtures is important in pharmaceutical manufacturing and analysis. We previously demonstrated the feasibility of using Raman ...
Rapid quantification of tryptophan and tyrosine in chemically defined cell culture media using fluorescence spectroscopy
(2012)
The rapid and inexpensive analysis of the complex cell culture media used in industrial mammalian cell culture is required for quality and variance monitoring. Excitation-emission matrix (EEM) spectroscopy combined with ...
Time-domain measurement of fluorescence lifetime variation with pH
(Society of Photo-optical Instrumentation Engineers, 2001)
Advances in the design and miniaturization of the lasers and electronics required for Time Correlated Single Photon Counting (TCSPC) measurement of fluorescence lifetime have simplified the use of the time domain method. ...
Fluorescence emission from petroleum; a valuable information source for petroleum analysis.
(EniTecnologie, 2004)
Despite the fact that most crude oils are dark coloured liquids, many are observed to be strongly fluorescent when illuminated with UV light. This fluorescence, which originates from the presence of aromatic compounds, is ...