School of Chemistry (Scholarly Articles)
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Accurate anisotropy recovery from fluorophore mixtures using Multivariate Curve Resolution (MCR)
(Elsevier, 2017-11-22)Anisotropy resolved multidimensional emission spectroscopy (ARMES) provides valuable insights into multi-fluorophore systems like proteins that have complex overlapping emission bands. The method combines multidimensional ... -
A Bpp-based dinuclear ruthenium photocatalyst for visible light-driven oxidation reactions
(Royal Society of Chemistry, 2019-11-05)A diruthenium dyad molecule consisting of a 2,2-(1H-pyrazole-3,5-diyl)dipyridine (Hbpp) bridging ligand with the formula out-/in-[(bpy)2Ru(bpp)Ru(L)(tpy)]n+ (bpy = 2,2′-bipyridine, tpy = 2,2′:6′,2′′-terpyridine, L = Cl, ... -
Electrolysis of low-grade and saline surface water
(Nature Research (part of Springer Nature), 2020-02-17)Review Article Published: 17 February 2020 Electrolysis of low-grade and saline surface water Wenming Tong, Mark Forster, Fabio Dionigi, Sören Dresp, Roghayeh Sadeghi Erami, Peter Strasser, Alexander J. Cowan & Pau ... -
Supramolecular stacking in a high Z′ calix[8]arene–porphyrin assembly
(Royal Society of Chemistry, 2019-11-15)A co-crystal structure of sulfonato-calix[8]arene (sclx8) and trimethylanilinium-porphyrin (tmap) at 1.0 Å resolution is reported. The oppositely charged macrocycles formed an alternating stacked assembly. Crystal packing ... -
Tuning protein frameworks via auxiliary supramolecular interactions
(American Chemical Society, 2019-09-06)Protein crystals with their precise, periodic array of functional building blocks have potential applications in biomaterials, sensing, and catalysis. This paper describes how a highly porous crystalline framework of a ... -
Calixarene-mediated assembly of a small antifungal protein
(International Union of Crystallography, 2019-02-05)Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by providing a surface on which two or more ... -
Investigating native state fluorescence emission of Immunoglobulin G using polarized Excitation Emission Matrix (pEEM) spectroscopy and PARAFAC
(Elsevier, 2018-12-20)Intrinsic fluorescence spectroscopy (IFS) measurements for protein structural analysis can be enhanced by the use of anisotropy resolved multidimensional emission spectroscopy (ARMES). ARMES attempts to overcome the ... -
Multi-attribute quality screening of immunoglobulin G using polarized Excitation Emission Matrix spectroscopy
(Elsevier, 2019-12-10)Immunoglobulin G (IgG) is often used as a starting material for the production of functionalised antibodies, like Antibody Drug Conjugates (ADCs), PEGlyated-conjugates, or radioimmunoconjugates. The gross structural quality ... -
Using polarized Total Synchronous Fluorescence Spectroscopy (pTSFS) with PARAFAC analysis for characterizing intrinsic protein emission
(Elsevier, 2019-10-15)Using polarized Excitation Emission Matrix (pEEM) spectroscopy to measure the intrinsic emission of proteins offers a potentially useful methodology for a wide variety of potential applications. However, the presence of ... -
An experimental and kinetic modeling study of the oxidation of hexane isomers: Developing consistent reaction rate rules for alkanes
(Elsevier, 2019-05-09)Alkanes are key components in gasoline, jet and diesel fuels and considerably influence the combustion behavior of these fuels because of their wide range of reactivity. An improved understanding of their combustion behavior ... -
The air-water interface stabilizes α-helical conformations of the insulin B-chain
(AIP Publishing, 2019-08-09)Adsorption of proteins onto liquid interfaces, such as the air-water interface, often leads to changes in the protein conformation. This can lead to changes in protein assembly behaviour, with aggregation and fibrillation ... -
Metal-based glycoconjugates and their potential in targeted anticancer chemotherapy
(De Gruyter Open, 2016-04-07)Glucose is a key source of energy and an essential nutrient for cell growth. Rapidly dividing cancer cells are well-known to require more nutrients and energy than normal ones to sustain their higher proliferation ... -
Effect of individual plasma components on the performance of a glucose enzyme electrode based on redox polymer mediation of a flavin adenine dinucleotide-dependent glucose dehydrogenase
(Elsevier, 2019-02-11)The performance of glucose enzyme electrodes, consisting of crosslinked flavin adenine dinucleotide glucose dehydrogenase (FADGDH), an osmium redox polymer and multi-walled carbon nanotubes on graphite electrodes, was ... -
Glucose biosensor based on open-source wireless microfluidic potentiostat
(Elsevier, 2019-02-17)Wireless potentiostats capable of cyclic voltammetry and amperometry that connect to the Internet are emerging as key attributes of future point-of-care devices. This work presents an "integrated microfluidic electrochemical ... -
The influence of surface composition of carbon nanotubes on the photobioelectrochemical activity of thylakoid bioanodes mediated by osmium-complex modified redox polymer
(Elsevier, 2019-04-17)A combination of photosynthetic biocatalysts with high surface area conductive materials mediated by an osmium-complex modified redox polymer (OsRP) holds promising features for the development of sustainable "green" systems ... -
A thermodynamic model of auto-regulated protein assembly by a supramolecular scaffold
(Wiley, 2019-03-12)Ligand-mediated regulation of protein assembly occurs frequently in different cellular contexts. Auto-regulated assembly, where a ligand acts as its own competitive inhibitor, provides a mechanism for exquisite control of ... -
Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
(Elsevier, 2019-02-23)The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ... -
Conversion of gel-forming crystal needles to easily processable more equant crystals Using high-shear ultralow attrition agitation: accelerated Ostwald ripening without crystal attrition
(American Chemical Society, 2019-02-01)We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution ... -
Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid
(Elsevier, 2019-04-19)The coordination of biologically active moieties to the axial positions of Pt(IV) derivatives of Pt(II) anticancer drugs allows the co-delivery and simultaneous activation of two pro-drugs for combination therapy. Pt(IV) ... -
Ligand design for somatostatin receptor isoforms 4 and 5
(Elsevier, 2018-11-17)The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and ...