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Smg1 haploinsufficiency predisposes to tumor formation and inflammation
(Proceedings of the National Academy of Sciences, 2012-12-31)
SMG1 is a member of the phosphoinositide kinase-like kinase family of proteins that includes ATM, ATR, and DNA-PK, proteins with known roles in DNA damage and cellular stress responses. SMG1 has a well-characterized role ...
Evolution of astacin-like metalloproteases in animals and their function in development
(Wiley-Blackwell, 2006-03-01)
Astacin-like metalloproteases are ubiquitous in the animal kingdom but their phylogenetic relationships and ancient functions within the Metazoa are unclear. We have cloned and characterized four astacin-like cDNAs from ...
Dual ire1 rnase functions dictate glioblastoma development
(EMBO, 2018-01-08)
Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
(Royal Society of Chemistry (RSC), 2009-01-01)
The conjugation of carbohydrates to synthetic scaffolds has the goal of preparing potent inhibitors of lectin binding. We herein report the synthesis of a panel of bivalent compounds (cyclophane and terephthalamide-derivatives) ...
Insulin-like growth factor (igf) signalling is required for early dorso-anterior development of the zebrafish embryo
(UPV/EHU Press, 2004-01-01)
The insulin-like growth factor (IGF) signalling pathway has been highly conserved in animal evolution and, in mammals and Xenopus, plays a key role in embryonic growth and development, with the IGF-1 receptor (IGF-1R) being ...
Lewis x structures in the o antigen side-chain promote adhesion of helicobacter pylori to the gastric epithelium
(Wiley-Blackwell, 2002-01-18)
Helicobacter pylori NCTC11637 expresses a lipopolysaccharide (LPS) that comprises an O antigen side-chain with structural homology to the human blood group antigen Lewis X (Le(x)). The role of this molecule in adhesion of ...
Specific pgf2αreceptor (fp) antagonism and human uterine contractilityin vitro
(Wiley-Blackwell, 2005-08-01)
Objective PGF(2 alpha) acts through its receptor, FP, as an important smooth muscle contractile agent. The aim of this study was to investigate the effects of specific FP antagonism, using the novel-specific FP non-competitive ...
Global effects of homocysteine on transcription in escherichia coli: induction of the gene for the major cold-shock protein, cspa
(Microbiology Society, 2006-08-01)
Homocysteine (Hey) is a thiol-containing amino acid that is considered to be medically important because it is linked to the development of several life-threatening diseases in humans, including cardiovascular disease and ...
Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
(Frontiers Media SA, 2017-08-21)
Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ...
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors
(Springer Nature, 2015-08-25)
Introduction: Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, ...