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Thiamine plays a critical role in the acid tolerance of listeria monocytogenes
(Oxford University Press (OUP), 2011-11-14)
Understanding the molecular basis of acid tolerance in the food-borne pathogen Listeria monocytogenes is important as this property contributes to survival in the food-chain and enhances survival within infected hosts. The ...
Single nucleotide polymorphisms within the bovine dlk1-dio3 imprinted domain are associated with economically important production traits in cattle
(Oxford University Press (OUP), 2010-09-03)
Previous studies show that DNA sequence variation within the mammalian DLK1-DIO3 imprinted domain influences production traits in domestic livestock, most notably the ovine callipyge phenotype. We assessed genotype-phenotype ...
Control of tnf-induced dendritic cell maturation by hybrid-type n-glycans
(The American Association of Immunologists, 2011-03-21)
The activity of alpha-1,2-mannosidase I is required for the conversion of high-mannose to hybrid-type (ConA reactive) and complex-type N-glycans (Phaseolus vulgaris-leukoagglutinin [PHA-L] reactive) during posttranslational ...
Mutations in the genes for oocyte-derived growth factors gdf9 and bmp15 are associated with both increased ovulation rate and sterility in cambridge and belclare sheep (ovis aries)1
(Oxford University Press (OUP), 2004-04-01)
Belclare and Cambridge are prolific sheep breeds, the origins of which involved selecting ewes with exceptionally high litter size records from commercial flocks. The variation in ovulation rate in both breeds is consistent ...
Role of listeria monocytogenes b in survival of lethal acidic conditions and in the acquired acid tolerance response
(American Society for Microbiology, 2003-05-01)
The food-borne pathogen Listeria monocytogenes can acquire enhanced resistance to lethal acid conditions through multiple mechanisms. We investigated contributions of the stress-responsive alternative sigma factor, or ...
Meta-analysis confirms bcl2 is an independent prognostic marker in breast cancer
(Springer Nature, 2008-05-29)
Background: A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed ...
Micrornas as prognostic indicators and therapeutic targets: potential effect on breast cancer management
(American Association for Cancer Research (AACR), 2008-01-15)
The discovery of microRNAs (miRNA) as novel modulators of gene expression has resulted in a rapidly expanding repertoire of molecules in this family, as reflected in the concomitant expansion of scientific literature. ...
Ulk4 is essential for ciliogenesis and csf flow
(Society for Neuroscience, 2016-07-20)
Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three ...
5-hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due tostaphylococcus aureus
(Oxford University Press (OUP), 2016-12-20)
Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential ...