Now showing items 31-40 of 145
Sar150640, a selective β3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis
Background and purpose: The uterine pathophysiology underlying inflammatory conditions such as chorioamnionitis remains largely unclear. As we have shown that beta(3)-adrenoceptors act as regulators of myometrial inflammation, ...
Robust, efficient, and practical electrogene transfer method for human mesenchymal stem cells using square electric pulses
(Mary Ann Liebert Inc, 2013-10-01)
Mesenchymal stem cells (MSCs) are multipotent nonhematopoietic cells with the ability to differentiate into various specific cell types, thus holding great promise for regenerative medicine. Early clinical trials have ...
Ulk4 is essential for ciliogenesis and csf flow
(Society for Neuroscience, 2016-07-20)
Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three ...
Facets of diazotrophy in the oxygen minimum zone waters off peru
(Springer Nature, 2014-05-09)
Nitrogen fixation, the biological reduction of dinitrogen gas (N-2) to ammonium (NH4+), is quantitatively the most important external source of new nitrogen (N) to the open ocean. Classically, the ecological niche of oceanic ...
Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-tnfα drug
(Elsevier BV, 2015-09-01)
5-hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due tostaphylococcus aureus
(Oxford University Press (OUP), 2016-12-20)
Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential ...
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
(Springer Nature, 2016-06-21)
Background: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. Method: We performed a fine-scale ...
Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
(Frontiers Media SA, 2017-08-21)
Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ...
Development of a cucumis sativus tilling platform for forward and reverse genetics
(Public Library of Science (PLoS), 2014-05-16)
Background: Cucumber (Cucumis sativus) belongs to the Cucurbitaceae family that includes more than 800 species. The cucumber genome has been recently sequenced and annotated. Transcriptomics and genome sequencing of many ...
Evidence for intron length conservation in a set of mammalian genes associated with embryonic development
(Springer Nature, 2011-01-01)
Background: We carried out an analysis of intron length conservation across a diverse group of nineteen mammalian species. Motivated by recent research suggesting a role for time delays associated with intron transcription ...