Now showing items 141-145 of 145
Top2a amplification in the absence of that of her-2/neu: toward individualization of chemotherapeutic practice in breast cancer
(Alphamed Press, 2011-06-24)
Primary objective. To investigate the relationship between human epidermal growth factor receptor (HER)-2/neu and the gene encoding topoisomerase II alpha (TOP2A) in breast cancer, while elucidating their association with ...
Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm
(The Company of Biologists, 2012-02-08)
It is still controversial whether cranial placodes and neural crest cells arise from a common precursor at the neural plate border or whether placodes arise from non-neural ectoderm and neural crest from neural ectoderm. ...
Perk regulated mir-424(322)-503 cluster fine-tunes activation of ire1 and atf6 during unfolded protein response
(Springer Nature, 2015-12-17)
The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ...
Perk-dependent repression of mir-106b-25 cluster is required for er stress-induced apoptosis
(Springer Nature, 2012-06-01)
Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ...
Ncoa3 coactivator is a transcriptional target of xbp1 and regulates perk–eif2α–atf4 signalling in breast cancer
(Springer Nature, 2016-04-25)
XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about ...