Now showing items 31-40 of 148
Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-tnfα drug
(Elsevier BV, 2015-09-01)
Fine-scale mapping of the fgfr2 breast cancer risk locus: putative functional variants differentially bind foxa1 and e2f1
(Elsevier BV, 2013-12-01)
The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies ...
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
(Springer Nature, 2013-03-27)
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for similar to 9% of the familial risk of the ...
Compartmental oxidation of thiol–disulphide redox couples during epidermal growth factor signalling
(Portland Press Ltd., 2005-03-01)
Exogenously added ROS (reactive oxygen species) cause generalized oxidation of cellular components, whereas endogenously generated ROS induced by physiological stimuli activate discrete signal transduction pathways. ...
Chemical structures of the core regions of campylobacter jejuni serotypes o:1, o:4, o:23, and o:36 lipopolysaccharides
Complete structures, including the location of N-acetylneuraminic acid (Neu5Ac) residues, were assigned for the core regions of Campylobacter jejuni serotypes 0:1, 0:4, and 0:23 and 0:36 lipopolysaccharides (LPS). In ...
Insulin-like growth factor (igf) signalling is required for early dorso-anterior development of the zebrafish embryo
(UPV/EHU Press, 2004-01-01)
The insulin-like growth factor (IGF) signalling pathway has been highly conserved in animal evolution and, in mammals and Xenopus, plays a key role in embryonic growth and development, with the IGF-1 receptor (IGF-1R) being ...
Lewis x structures in the o antigen side-chain promote adhesion of helicobacter pylori to the gastric epithelium
Helicobacter pylori NCTC11637 expresses a lipopolysaccharide (LPS) that comprises an O antigen side-chain with structural homology to the human blood group antigen Lewis X (Le(x)). The role of this molecule in adhesion of ...
Role of listeria monocytogenes b in survival of lethal acidic conditions and in the acquired acid tolerance response
(American Society for Microbiology, 2003-05-01)
The food-borne pathogen Listeria monocytogenes can acquire enhanced resistance to lethal acid conditions through multiple mechanisms. We investigated contributions of the stress-responsive alternative sigma factor, or ...
Specific pgf2αreceptor (fp) antagonism and human uterine contractilityin vitro
Objective PGF(2 alpha) acts through its receptor, FP, as an important smooth muscle contractile agent. The aim of this study was to investigate the effects of specific FP antagonism, using the novel-specific FP non-competitive ...
Global effects of homocysteine on transcription in escherichia coli: induction of the gene for the major cold-shock protein, cspa
(Microbiology Society, 2006-08-01)
Homocysteine (Hey) is a thiol-containing amino acid that is considered to be medically important because it is linked to the development of several life-threatening diseases in humans, including cardiovascular disease and ...