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Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
(Springer, 2009-01-08)
Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant
morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour
are ...
Expression of RHOGTPase regulators in human myometrium
(Reproductive Biology and Endocrinology, 2008-01-11)
Background: RHOGTPases play a significant role in modulating myometrial contractility in
uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine
nucleotide exchange factors (RHOGEFs), ...
Analysis of Maxi-K alpha subunit splice variants in human myometrium
(springer, 2004-09-21)
Background: Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated
in the modulation of human uterine contractions and myometrial Ca2+ homeostasis. However, the
regulatory mechanism(s) governing ...
Ghrelin in the human myometrium
(BioMed Central Ltd, 2010-03-29)
Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ...
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
(2009)
Objectives
Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine ...
Differential expression of the metalloproteinase MMP3 and the a5 integrin subunit in human myometrium at labour
(Oxford University Press, 2007-09-13)
Extensive tissue remodelling occurs in the human myometrium before, during and after parturition. The aim of this study was to investigate the expression of two tissue remodelling molecules, matrix metalloproteinase 3 ...
Ghrelin in the human myometrium
(2010)
Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously ...
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
(BioMed Central, 2009-01-08)
Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not ...
Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction
(Society for Reproduction and Fertility, 2006-07-01)
Pre eclampsia represents a state of increased or prolonged vasoconstriction, partially linked to the potent vasocontractile effect of isoprostanes. The process of Rho A-mediated calcium sensitisation is inherent to a state ...
Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes
(Endocrine Society, 2005-07-02)
Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role in modulating cell membrane potential and ...