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Am I being watched? The role of researcher presence on toddlers’ behaviour during ‘everyday’ pain experiences: a pilot study
(Taylor & Francis, 2019-12-31)
Objective: Paediatric research on 'everyday' pain experiences is sparse, stemming from a lack of appropriate methodologies. We explored the feasibility of two methodologies for conducting naturalistic observations of ...
How exactly do politics play a part in determining health? New perspectives on an age old issue.
(BMJ Group, 2002-06)
This is the latest study to demonstrate an association between type of political pattern and health status, in this case suicide. Previous studies have also identified a more general relation between party political voting ...
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
(Elsevier, 2017-02-22)
Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ...
Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients
(Wiley, 2013-02-21)
Background and Aim
TRIM28 is a multi‐domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in epithelial and stromal tumor microenvironment and its prognostic role ...
Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's disease
(Lippincott, Williams & Wilkins, 2016-09-01)
The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor ...
Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
(Elsevier, 2018-10-05)
Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ...
Ulk4 regulates GABAergic signaling and anxiety-related behavior
(Springer Nature, 2018-02-02)
Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ...
FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex
(Wiley, 2017-07-20)
Toll-like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3-induced inflammatory, endocrine, and sickness responses. ...
High times for painful blues: the endocannabinoid system in pain-depression comorbidity
(Oxford University Press (OUP), 2015-09-05)
Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability ...
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
(Karger Publishers, 2017-10-24)
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ...