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dc.contributor.authorGorman, Adrienne
dc.contributor.authorHillis, Jennifer
dc.contributor.authorO'Dwyer, Michael
dc.date.accessioned2016-01-21T14:53:27Z
dc.date.issued2015-09-23
dc.identifier.citationHillis J, O'Dwyer M, Gorman AM. (2015) 'Neurotrophins and B-cell malignancies'. Cellular And Molecular Life Sciences.en_IE
dc.identifier.issn1420-9071
dc.identifier.urihttp://hdl.handle.net/10379/5477
dc.description.abstractNeurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro and mature forms, and can act in an autocrine or paracrine fashion. The p75NTR and Trk receptors can elicit signalling in response to the presence or absence of their corresponding neurotrophin ligands. This signalling, along with neurotrophin and receptor expression, varies between different cell types. Neurotrophins and their receptors have been shown to be expressed by and elicit signalling in B lymphocytes. In general, most neurotrophins are expressed by activated B cells and memory B cells. Likewise, the TrkB95 receptor is seen on activated B cells, while TrkA and p75NTR are expressed by both resting and active B cells as well as memory B cells. Nerve growth factor stimulates B cell proliferation, memory B cell survival, antibody production and CD40 expression. Brain derived neurotrophic factor is involved in B cell maturation in the bone marrow through TrkB95. Overall neurotrophins and their receptors have been shown to be involved in B cell proliferation, development, differentiation, antibody secretion and survival. As well as expression and activity in healthy B cells, the neurotrophins and their receptors can contribute to B cell malignancies including acute lymphoblastic leukaemia, diffuse large B cell lymphoma, Burkitt’s lymphoma and multiple myeloma. They are involved in B cell malignancy survival and potentially in drug resistance.en_IE
dc.description.sponsorshipMolecular Medicine Ireland as part of the Clinical & Translational Research Scholars Programmeen_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherSpringer Verlagen_IE
dc.relation.ispartofCellular And Molecular Life Sciencesen
dc.subjectNeurotrophinsen_IE
dc.subjectNerve Growth Factor (NGF)en_IE
dc.subjectTropomyosin Related Kinase (Trk) Receptorsen_IE
dc.subjectp75NTRen_IE
dc.subjectB lymphocytesen_IE
dc.subjectB cell malignanciesen_IE
dc.subjectBiochemistryen_IE
dc.titleNeurotrophins and B-cell malignanciesen_IE
dc.typeArticleen_IE
dc.date.updated2016-01-21T14:37:53Z
dc.identifier.doiDOI 10.1007/s00018-015-2046-4
dc.local.publishedsourcehttp://dx.doi.org/ 10.1007/s00018-015-2046-4en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.description.embargo2016-09-23
dc.internal.rssid10242750
dc.local.contactAdrienne Gorman, Biochemistry, School Of Natural Science, Bioresearch Building, Nui. 2417 Email: adrienne.gorman@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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