Biochemistry (Scholarly Articles)
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RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster
(eLife Sciences Publications, 2019-11-05)Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that ... -
Determination of the number of RAD51 molecules in different human cell lines
(Taylor & Francis, 2019-11-15)Knowledge about precise numbers of specific molecules is necessary for understanding and verification of biological pathways. The RAD51 protein is central in the repair of DNA double-strand breaks (DSBs) by homologous ... -
ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn2+
(Wiley Open Access, 2019-08-29)B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone normally found in the ER lumen. However, BiP also has other extracellular and intracellular functions. As it is unclear whether ... -
RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells
(Elsevier, 2018-02-06)Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ... -
Stress management at the ER: regulators of ER stress-induced apoptosis.
(Elsevier, 2012-02-17)The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are ... -
Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity
(Elsevier, 2017-11-03)Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ... -
Role of mitochondria in neuronal apoptosis
(Karger Publishers, 2000-12)Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged ... -
The integrated stress response
(EMBO Press, 2016-09-14)In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation ... -
Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells
(Elsevier, 2016)Triple negative breast cancer [TNBC] cells are reported to secrete the neurotrophin nerve growth factor [NGF] and express its receptors, p75 neurotrophin receptor [p75(NTR)] and TrkA, leading to NGF-activated pro-survival ... -
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
(Wiley, 2008-06-27)Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ... -
Neurotrophins and B-cell malignancies
(Springer Verlag, 2015-09-23)Neurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro and mature forms, and can act in an autocrine ... -
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
(Nature Publishing Group, 2014-05-01)Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ... -
Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State.
(2011)Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that ... -
The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis
(2011)Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents ... -
Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: Apoptosis induction by TRAIL
(American Society for Biochemistry and Molecular Biology, 2012)Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ... -
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants
(Macmillan Publishers Limited, 2010)The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered ... -
Nerve Growth Factor in Cancer Cell Death and Survival
(MDPI, 2011-02)One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that ... -
Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts
(2009)BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ... -
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
(2010)During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ... -
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
(2010)The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ...